Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes
There are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relations...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2187 |
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| author | O. Gamaliel Aztatzi-Aguilar Claudia Vargas-Domínguez Yazmin Debray-Garcia Manolo S. Ortega-Romero Paloma Almeda-Valdés Carlos A. Aguilar-Salinas M. Augusta Naranjo-Meneses D. Abril Mena-Orozco César E. Lam-Chung Ivette Cruz-Bautista M. Patricia Sierra-Vargas |
| author_facet | O. Gamaliel Aztatzi-Aguilar Claudia Vargas-Domínguez Yazmin Debray-Garcia Manolo S. Ortega-Romero Paloma Almeda-Valdés Carlos A. Aguilar-Salinas M. Augusta Naranjo-Meneses D. Abril Mena-Orozco César E. Lam-Chung Ivette Cruz-Bautista M. Patricia Sierra-Vargas |
| author_sort | O. Gamaliel Aztatzi-Aguilar |
| collection | DOAJ |
| description | There are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relationship between HRR and HRR-derived parameters in ambulatory patients with asthma or type 2 diabetes followed at the National Institutes of Health in Mexico City. A total of 78 participants, 50 women and, 28 men were enrolled; anthropometric, respiratory evaluations, and fasting blood samples were taken before participants performed a 6-min walking test (6MWT). Abnormal HRR was defined as a drop of ≤8 and ≤11 beats/min at 1 or 2 min and correlated negatively with basal oxygen saturation at 1 min. Heart rate at 1 min, correlated negatively with final oxygen saturation (<i>p</i> < 0.01). Statistically significant negative correlations were also observed between red cell count and white blood cell count and HOMA-IR with a <i>p</i> < 0.01. Since discrete hematological but significant changes correlated with HRR and HRR-derived parameters, we consider that these measures are helpful in clinical settings to identify subclinical autonomic dysfunction that permits us to prevent or anticipate chronic and fatal clinical outcomes. |
| first_indexed | 2024-03-10T04:19:49Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:19:49Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4210d9432c874728a4e539e2f142a82d2023-11-23T07:52:37ZengMDPI AGDiagnostics2075-44182021-11-011112218710.3390/diagnostics11122187Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 DiabetesO. Gamaliel Aztatzi-Aguilar0Claudia Vargas-Domínguez1Yazmin Debray-Garcia2Manolo S. Ortega-Romero3Paloma Almeda-Valdés4Carlos A. Aguilar-Salinas5M. Augusta Naranjo-Meneses6D. Abril Mena-Orozco7César E. Lam-Chung8Ivette Cruz-Bautista9M. Patricia Sierra-Vargas10Departamento de Investigación en Toxicología y Medicina Ambiental, Instituto de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México 14080, MexicoDepartamento de Investigación en Toxicología y Medicina Ambiental, Instituto de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México 14080, MexicoDepartamento de Investigación en Toxicología y Medicina Ambiental, Instituto de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México 14080, MexicoDepartamento de Investigación en Toxicología y Medicina Ambiental, Instituto de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México 14080, MexicoUnidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoUnidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoUnidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoUnidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoUnidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoUnidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, MexicoSubdirección de Investigación Clínica, Instituto de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México 14080, MexicoThere are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relationship between HRR and HRR-derived parameters in ambulatory patients with asthma or type 2 diabetes followed at the National Institutes of Health in Mexico City. A total of 78 participants, 50 women and, 28 men were enrolled; anthropometric, respiratory evaluations, and fasting blood samples were taken before participants performed a 6-min walking test (6MWT). Abnormal HRR was defined as a drop of ≤8 and ≤11 beats/min at 1 or 2 min and correlated negatively with basal oxygen saturation at 1 min. Heart rate at 1 min, correlated negatively with final oxygen saturation (<i>p</i> < 0.01). Statistically significant negative correlations were also observed between red cell count and white blood cell count and HOMA-IR with a <i>p</i> < 0.01. Since discrete hematological but significant changes correlated with HRR and HRR-derived parameters, we consider that these measures are helpful in clinical settings to identify subclinical autonomic dysfunction that permits us to prevent or anticipate chronic and fatal clinical outcomes.https://www.mdpi.com/2075-4418/11/12/2187biochemical evaluationhematological evaluationautonomic dysfunctionheart rate recovery6-min walking test |
| spellingShingle | O. Gamaliel Aztatzi-Aguilar Claudia Vargas-Domínguez Yazmin Debray-Garcia Manolo S. Ortega-Romero Paloma Almeda-Valdés Carlos A. Aguilar-Salinas M. Augusta Naranjo-Meneses D. Abril Mena-Orozco César E. Lam-Chung Ivette Cruz-Bautista M. Patricia Sierra-Vargas Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes Diagnostics biochemical evaluation hematological evaluation autonomic dysfunction heart rate recovery 6-min walking test |
| title | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
| title_full | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
| title_fullStr | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
| title_full_unstemmed | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
| title_short | Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes |
| title_sort | biochemical and hematological relationship with the evaluation of autonomic dysfunction by heart rate recovery in patients with asthma and type 2 diabetes |
| topic | biochemical evaluation hematological evaluation autonomic dysfunction heart rate recovery 6-min walking test |
| url | https://www.mdpi.com/2075-4418/11/12/2187 |
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