Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis
The immune system is increasingly recognized for its role in the genesis and progression of hypertension. The adrenal gland is a major site that coordinates the stress response via the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal system. Catecholamines released from the adrenal me...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00343/full |
| _version_ | 1818910843850457088 |
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| author | Collin J. Byrne Sandhya Khurana Aseem Kumar Aseem Kumar T. C. Tai T. C. Tai T. C. Tai T. C. Tai |
| author_facet | Collin J. Byrne Sandhya Khurana Aseem Kumar Aseem Kumar T. C. Tai T. C. Tai T. C. Tai T. C. Tai |
| author_sort | Collin J. Byrne |
| collection | DOAJ |
| description | The immune system is increasingly recognized for its role in the genesis and progression of hypertension. The adrenal gland is a major site that coordinates the stress response via the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal system. Catecholamines released from the adrenal medulla function in the neuro-hormonal regulation of blood pressure and have a well-established link to hypertension. The immune system has an active role in the progression of hypertension and cytokines are powerful modulators of adrenal cell function. Adrenal medullary cells integrate neural, hormonal, and immune signals. Changes in adrenal cytokines during the progression of hypertension may promote blood pressure elevation by influencing catecholamine biosynthesis. This review highlights the potential interactions of cytokine signaling networks with those of catecholamine biosynthesis within the adrenal, and discusses the role of cytokines in the coordination of blood pressure regulation and the stress response. |
| first_indexed | 2024-12-19T22:49:15Z |
| format | Article |
| id | doaj.art-421420785c32415598ab95c197c6f661 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-19T22:49:15Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-421420785c32415598ab95c197c6f6612022-12-21T20:02:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-06-01910.3389/fendo.2018.00343371164Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine BiosynthesisCollin J. Byrne0Sandhya Khurana1Aseem Kumar2Aseem Kumar3T. C. Tai4T. C. Tai5T. C. Tai6T. C. Tai7Department of Biology, Laurentian University, Sudbury, ON, CanadaMedical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON, CanadaDepartment of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, CanadaBiomolecular Sciences Program, Laurentian University, Sudbury, ON, CanadaDepartment of Biology, Laurentian University, Sudbury, ON, CanadaMedical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON, CanadaDepartment of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, CanadaBiomolecular Sciences Program, Laurentian University, Sudbury, ON, CanadaThe immune system is increasingly recognized for its role in the genesis and progression of hypertension. The adrenal gland is a major site that coordinates the stress response via the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal system. Catecholamines released from the adrenal medulla function in the neuro-hormonal regulation of blood pressure and have a well-established link to hypertension. The immune system has an active role in the progression of hypertension and cytokines are powerful modulators of adrenal cell function. Adrenal medullary cells integrate neural, hormonal, and immune signals. Changes in adrenal cytokines during the progression of hypertension may promote blood pressure elevation by influencing catecholamine biosynthesis. This review highlights the potential interactions of cytokine signaling networks with those of catecholamine biosynthesis within the adrenal, and discusses the role of cytokines in the coordination of blood pressure regulation and the stress response.https://www.frontiersin.org/article/10.3389/fendo.2018.00343/fullhypertensionadrenal medullacatecholamineimmunecytokineglucocorticoid |
| spellingShingle | Collin J. Byrne Sandhya Khurana Aseem Kumar Aseem Kumar T. C. Tai T. C. Tai T. C. Tai T. C. Tai Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis Frontiers in Endocrinology hypertension adrenal medulla catecholamine immune cytokine glucocorticoid |
| title | Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis |
| title_full | Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis |
| title_fullStr | Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis |
| title_full_unstemmed | Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis |
| title_short | Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis |
| title_sort | inflammatory signaling in hypertension regulation of adrenal catecholamine biosynthesis |
| topic | hypertension adrenal medulla catecholamine immune cytokine glucocorticoid |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00343/full |
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