Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states
Small heat shock proteins (sHSPs) are nature’s ‘first responders’ to cellular stress, interacting with affected proteins to prevent their aggregation. Little is known about sHSP structure beyond its structured α-crystallin domain (ACD), which is flanked by disordered regions. In the human sHSP HSPB1...
Main Authors: | Amanda F Clouser, Hannah ER Baughman, Benjamin Basanta, Miklos Guttman, Abhinav Nath, Rachel E Klevit |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/50259 |
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