Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
Abstract Soluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets....
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Format: | Article |
Language: | English |
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Nature Publishing Group
2024-01-01
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Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-023-01150-6 |
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author | Eun-Ji Park Chang-Woo Lee |
author_facet | Eun-Ji Park Chang-Woo Lee |
author_sort | Eun-Ji Park |
collection | DOAJ |
description | Abstract Soluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets. We provide an overview of the mechanisms by which soluble receptors are generated along with their functions. By exploring their involvement in cancer progression, metastasis, and immune evasion, we highlight the importance of soluble receptors, particularly soluble cytokine receptors and immune checkpoints, in the tumor microenvironment. Although current research has illustrated the emerging clinical relevance of soluble receptors, their therapeutic applications remain underexplored. As the landscape of cancer treatment evolves, understanding and targeting soluble receptors might pave the way for novel strategies for cancer diagnosis, prognosis, and therapy. |
first_indexed | 2024-03-07T15:17:55Z |
format | Article |
id | doaj.art-4216433d09ff478c82845548e33758fe |
institution | Directory Open Access Journal |
issn | 2092-6413 |
language | English |
last_indexed | 2024-03-07T15:17:55Z |
publishDate | 2024-01-01 |
publisher | Nature Publishing Group |
record_format | Article |
series | Experimental and Molecular Medicine |
spelling | doaj.art-4216433d09ff478c82845548e33758fe2024-03-05T17:47:51ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-01-0156110010910.1038/s12276-023-01150-6Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategiesEun-Ji Park0Chang-Woo Lee1Department of Molecular Cell Biology, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineAbstract Soluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets. We provide an overview of the mechanisms by which soluble receptors are generated along with their functions. By exploring their involvement in cancer progression, metastasis, and immune evasion, we highlight the importance of soluble receptors, particularly soluble cytokine receptors and immune checkpoints, in the tumor microenvironment. Although current research has illustrated the emerging clinical relevance of soluble receptors, their therapeutic applications remain underexplored. As the landscape of cancer treatment evolves, understanding and targeting soluble receptors might pave the way for novel strategies for cancer diagnosis, prognosis, and therapy.https://doi.org/10.1038/s12276-023-01150-6 |
spellingShingle | Eun-Ji Park Chang-Woo Lee Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies Experimental and Molecular Medicine |
title | Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies |
title_full | Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies |
title_fullStr | Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies |
title_full_unstemmed | Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies |
title_short | Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies |
title_sort | soluble receptors in cancer mechanisms clinical significance and therapeutic strategies |
url | https://doi.org/10.1038/s12276-023-01150-6 |
work_keys_str_mv | AT eunjipark solublereceptorsincancermechanismsclinicalsignificanceandtherapeuticstrategies AT changwoolee solublereceptorsincancermechanismsclinicalsignificanceandtherapeuticstrategies |