Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies

Abstract Soluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets....

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Main Authors: Eun-Ji Park, Chang-Woo Lee
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-01150-6
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author Eun-Ji Park
Chang-Woo Lee
author_facet Eun-Ji Park
Chang-Woo Lee
author_sort Eun-Ji Park
collection DOAJ
description Abstract Soluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets. We provide an overview of the mechanisms by which soluble receptors are generated along with their functions. By exploring their involvement in cancer progression, metastasis, and immune evasion, we highlight the importance of soluble receptors, particularly soluble cytokine receptors and immune checkpoints, in the tumor microenvironment. Although current research has illustrated the emerging clinical relevance of soluble receptors, their therapeutic applications remain underexplored. As the landscape of cancer treatment evolves, understanding and targeting soluble receptors might pave the way for novel strategies for cancer diagnosis, prognosis, and therapy.
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spelling doaj.art-4216433d09ff478c82845548e33758fe2024-03-05T17:47:51ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-01-0156110010910.1038/s12276-023-01150-6Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategiesEun-Ji Park0Chang-Woo Lee1Department of Molecular Cell Biology, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineAbstract Soluble receptors are soluble forms of receptors found in the extracellular space. They have emerged as pivotal regulators of cellular signaling and disease pathogenesis. This review emphasizes their significance in cancer as diagnostic/prognostic markers and potential therapeutic targets. We provide an overview of the mechanisms by which soluble receptors are generated along with their functions. By exploring their involvement in cancer progression, metastasis, and immune evasion, we highlight the importance of soluble receptors, particularly soluble cytokine receptors and immune checkpoints, in the tumor microenvironment. Although current research has illustrated the emerging clinical relevance of soluble receptors, their therapeutic applications remain underexplored. As the landscape of cancer treatment evolves, understanding and targeting soluble receptors might pave the way for novel strategies for cancer diagnosis, prognosis, and therapy.https://doi.org/10.1038/s12276-023-01150-6
spellingShingle Eun-Ji Park
Chang-Woo Lee
Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
Experimental and Molecular Medicine
title Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
title_full Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
title_fullStr Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
title_full_unstemmed Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
title_short Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
title_sort soluble receptors in cancer mechanisms clinical significance and therapeutic strategies
url https://doi.org/10.1038/s12276-023-01150-6
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