Three-Dimensional Liver Culture Systems to Maintain Primary Hepatic Properties for Toxicological Analysis In Vitro
Drug-induced liver injury (DILI) is the major reason for failures in drug development and withdrawal of approved drugs from the market. Two-dimensional cultures of hepatocytes often fail to reliably predict DILI: hepatoma cell lines such as HepG2 do not reflect important primary-like hepatic propert...
Main Author: | Sarah Kammerer |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/19/10214 |
Similar Items
-
The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity
by: Tamás Lőrincz, et al.
Published: (2021-08-01) -
Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence as a Capable Application for Energy Metabolism Experiments in In Vitro Oncologic Liver Models
by: Andrea Scheffschick, et al.
Published: (2022-08-01) -
Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells
by: Katherine D. Lynch, et al.
Published: (2023-07-01) -
Application of In Vitro Metabolism Activation in High-Throughput Screening
by: Masato Ooka, et al.
Published: (2020-10-01) -
Activation of Polyamine Catabolism by N<sup>1</sup>,N<sup>11</sup>-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype
by: Olga N. Ivanova, et al.
Published: (2018-12-01)