Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis

Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis

Aging-elevated DNMT3A R882H-driven clonal hematopoiesis (CH) is a risk factor for myeloid malignancies remission and overall survival. Although some studies were conducted to investigate this phenomenon, the exact mechanism is still under debate. In this study, we observed that DNMT3A R878H bone mar...

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Bibliographic Details
Main Authors: Min Liao, Ruiqing Chen, Yang Yang, Hanqing He, Liqian Xu, Yuxuan Jiang, Zhenxing Guo, Wei He, Hong Jiang, Jianwei Wang
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Aging
Inflammation
DNMT3A R882H
Clonal hematopoiesis
Hematopoietic stem cells
Necroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521003579

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