Experience in treating drug-resistant tuberculosis in patients with HIV infection
The paper describes the experience in treating 30 patients with drug- and multidrug-resistant tuberculosis and HIV infection (median CD4+ lymphocyte count was 629 cells/µl; 8 patients received antiretroviral therapy). Only 11 (36.7%) patients effectively completed a basic treatment cycle; failing th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2014-12-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/319 |
| Summary: | The paper describes the experience in treating 30 patients with drug- and multidrug-resistant tuberculosis and HIV infection (median CD4+ lymphocyte count was 629 cells/µl; 8 patients received antiretroviral therapy). Only 11 (36.7%) patients effectively completed a basic treatment cycle; failing therapy was stated in 3 (10%) patients and it was associated with the amplification of drug resistance (n = 2) and progressive tuberculosis with generalization in a patient with low baseline CD4+ lymphocyte counts (101 cells/µl) (n = 1); early treatment termination was seen in 16 (53.3%) cases. Fourteen (46.7%) patients were noted to have adverse events of treatment with second-line (reserve) drugs, among which allergic reactions were prevalent (n = 7 (23.3%)). |
|---|---|
| ISSN: | 2075-1230 2542-1506 |