Experience in treating drug-resistant tuberculosis in patients with HIV infection
The paper describes the experience in treating 30 patients with drug- and multidrug-resistant tuberculosis and HIV infection (median CD4+ lymphocyte count was 629 cells/µl; 8 patients received antiretroviral therapy). Only 11 (36.7%) patients effectively completed a basic treatment cycle; failing th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2014-12-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/319 |
| _version_ | 1826563165798793216 |
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| author | A. I. Gordon I. B. Viktorova S. A. Dolgikh |
| author_facet | A. I. Gordon I. B. Viktorova S. A. Dolgikh |
| author_sort | A. I. Gordon |
| collection | DOAJ |
| description | The paper describes the experience in treating 30 patients with drug- and multidrug-resistant tuberculosis and HIV infection (median CD4+ lymphocyte count was 629 cells/µl; 8 patients received antiretroviral therapy). Only 11 (36.7%) patients effectively completed a basic treatment cycle; failing therapy was stated in 3 (10%) patients and it was associated with the amplification of drug resistance (n = 2) and progressive tuberculosis with generalization in a patient with low baseline CD4+ lymphocyte counts (101 cells/µl) (n = 1); early treatment termination was seen in 16 (53.3%) cases. Fourteen (46.7%) patients were noted to have adverse events of treatment with second-line (reserve) drugs, among which allergic reactions were prevalent (n = 7 (23.3%)). |
| first_indexed | 2024-03-12T03:30:42Z |
| format | Article |
| id | doaj.art-4218f182e12e4d0cbb2cb084f38dac46 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:59:38Z |
| publishDate | 2014-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-4218f182e12e4d0cbb2cb084f38dac462025-03-02T11:22:21ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-12-010126668319Experience in treating drug-resistant tuberculosis in patients with HIV infectionA. I. Gordon0I. B. Viktorova1S. A. Dolgikh2ГКУЗ КО «Новокузнецкий клинический противотуберкулезный диспансер»ГБОУ ДПО «Новокузнецкий государственный институт усовершенствования врачей» МЗ и СР РФГБОУ ДПО «Новокузнецкий государственный институт усовершенствования врачей» МЗ и СР РФThe paper describes the experience in treating 30 patients with drug- and multidrug-resistant tuberculosis and HIV infection (median CD4+ lymphocyte count was 629 cells/µl; 8 patients received antiretroviral therapy). Only 11 (36.7%) patients effectively completed a basic treatment cycle; failing therapy was stated in 3 (10%) patients and it was associated with the amplification of drug resistance (n = 2) and progressive tuberculosis with generalization in a patient with low baseline CD4+ lymphocyte counts (101 cells/µl) (n = 1); early treatment termination was seen in 16 (53.3%) cases. Fourteen (46.7%) patients were noted to have adverse events of treatment with second-line (reserve) drugs, among which allergic reactions were prevalent (n = 7 (23.3%)).https://www.tibl-journal.com/jour/article/view/319drug-resistant tuberculosismultidrug resistancetreatmenthiv infection |
| spellingShingle | A. I. Gordon I. B. Viktorova S. A. Dolgikh Experience in treating drug-resistant tuberculosis in patients with HIV infection Туберкулез и болезни лёгких drug-resistant tuberculosis multidrug resistance treatment hiv infection |
| title | Experience in treating drug-resistant tuberculosis in patients with HIV infection |
| title_full | Experience in treating drug-resistant tuberculosis in patients with HIV infection |
| title_fullStr | Experience in treating drug-resistant tuberculosis in patients with HIV infection |
| title_full_unstemmed | Experience in treating drug-resistant tuberculosis in patients with HIV infection |
| title_short | Experience in treating drug-resistant tuberculosis in patients with HIV infection |
| title_sort | experience in treating drug resistant tuberculosis in patients with hiv infection |
| topic | drug-resistant tuberculosis multidrug resistance treatment hiv infection |
| url | https://www.tibl-journal.com/jour/article/view/319 |
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