Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma
Although the fundamental processes and chemical changes in metabolic programs have been elucidated in many cancers, the expression patterns of metabolism-related genes in head and neck squamous cell carcinoma (HNSCC) remain unclear. The mRNA expression profiles from the Cancer Genome Atlas included...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024036181 |
| _version_ | 1797224192362414080 |
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| author | Mengxian Jiang Xiang Gu Yexing Xu Jing Wang |
| author_facet | Mengxian Jiang Xiang Gu Yexing Xu Jing Wang |
| author_sort | Mengxian Jiang |
| collection | DOAJ |
| description | Although the fundamental processes and chemical changes in metabolic programs have been elucidated in many cancers, the expression patterns of metabolism-related genes in head and neck squamous cell carcinoma (HNSCC) remain unclear. The mRNA expression profiles from the Cancer Genome Atlas included 502 tumour and 44 normal samples were extracted. We explored the biological functions and prognosis roles of metabolism-associated genes in patients with HNSCC. The results indicated that patients with HNSCC could be divided into three molecular subtypes (C1, C2 and C3) based on 249 metabolism-related genes. There were markedly different clinical characteristics, prognosis outcomes, and biological functions among the three subtypes. Different molecular subtypes also have different tumour microenvironments and immune infiltration levels. The established prognosis model with 17 signature genes could predict the prognosis of patients with HNSCC and was validated using an independent cohort dataset. An individual risk scoring tool was developed using the risk score and clinical parameters; the risk score was an independent prognostic factor for patients with HNSCC. Different risk stratifications have different clinical characteristics, biological features, tumour microenvironments and immune infiltration levels. Our study could be used for clinical risk management and to help conduct precision medicine for patients with HNSCC. |
| first_indexed | 2024-04-24T13:49:13Z |
| format | Article |
| id | doaj.art-4218ff2719a54aa3aa9396518302bdde |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:49:13Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4218ff2719a54aa3aa9396518302bdde2024-04-04T05:05:12ZengElsevierHeliyon2405-84402024-03-01106e27587Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinomaMengxian Jiang0Xiang Gu1Yexing Xu2Jing Wang3Department of Otorhinolaryngology Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430000, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430000, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Maternal and Child Health of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 430000, China; Corresponding author. Maternal and Child Health of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, No.745, Wululu Road, Hongshan District, Wuhan, Hubei Province 430000, China.Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 430000, China; Corresponding author. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Road, Wuhan, Hubei Province 430000, China.Although the fundamental processes and chemical changes in metabolic programs have been elucidated in many cancers, the expression patterns of metabolism-related genes in head and neck squamous cell carcinoma (HNSCC) remain unclear. The mRNA expression profiles from the Cancer Genome Atlas included 502 tumour and 44 normal samples were extracted. We explored the biological functions and prognosis roles of metabolism-associated genes in patients with HNSCC. The results indicated that patients with HNSCC could be divided into three molecular subtypes (C1, C2 and C3) based on 249 metabolism-related genes. There were markedly different clinical characteristics, prognosis outcomes, and biological functions among the three subtypes. Different molecular subtypes also have different tumour microenvironments and immune infiltration levels. The established prognosis model with 17 signature genes could predict the prognosis of patients with HNSCC and was validated using an independent cohort dataset. An individual risk scoring tool was developed using the risk score and clinical parameters; the risk score was an independent prognostic factor for patients with HNSCC. Different risk stratifications have different clinical characteristics, biological features, tumour microenvironments and immune infiltration levels. Our study could be used for clinical risk management and to help conduct precision medicine for patients with HNSCC.http://www.sciencedirect.com/science/article/pii/S2405844024036181Head and neck squamous cell carcinomaMetabolismImmune infiltrationPrognosis model |
| spellingShingle | Mengxian Jiang Xiang Gu Yexing Xu Jing Wang Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma Heliyon Head and neck squamous cell carcinoma Metabolism Immune infiltration Prognosis model |
| title | Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma |
| title_full | Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma |
| title_fullStr | Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma |
| title_full_unstemmed | Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma |
| title_short | Metabolism-associated molecular classification and prognosis signature of head and neck squamous cell carcinoma |
| title_sort | metabolism associated molecular classification and prognosis signature of head and neck squamous cell carcinoma |
| topic | Head and neck squamous cell carcinoma Metabolism Immune infiltration Prognosis model |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024036181 |
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