An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium
Purpose: To report the structural and functional changes in a 67-year-old male with pentosan polysulfate sodium (PPS) maculopathy with a progressive resolution of bilateral vitelliform lesions after PPS cessation. Observations: The patient was initially seen after taking daily PPS for over 26 years....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245199362300083X |
| _version_ | 1797399067573092352 |
|---|---|
| author | Fritz Gerald P. Kalaw Nathan L. Scott Shyamanga Borooah |
| author_facet | Fritz Gerald P. Kalaw Nathan L. Scott Shyamanga Borooah |
| author_sort | Fritz Gerald P. Kalaw |
| collection | DOAJ |
| description | Purpose: To report the structural and functional changes in a 67-year-old male with pentosan polysulfate sodium (PPS) maculopathy with a progressive resolution of bilateral vitelliform lesions after PPS cessation. Observations: The patient was initially seen after taking daily PPS for over 26 years. Three months after discontinuing PPS, the bilateral vitelliform lesions identified on spectral-domain optical coherence tomography (SD-OCT) at initial consultation had completely resolved. Bilateral resolution of vitelliform lesions was associated with a decline in best-corrected visual acuity, and ellipsoid zone disruption on SD-OCT. Conclusions and importance: Several PPS maculopathy phenotypes have been previously described including vitelliform lesions. Our case highlights that discontinuing PPS may lead to rapid resolution of vitelliform lesions in PPS maculopathy and may be associated with a rapid reduction in vision. |
| first_indexed | 2024-03-09T01:34:06Z |
| format | Article |
| id | doaj.art-421a59e56ee9451497762c1c66c29d68 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-03-09T01:34:06Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-421a59e56ee9451497762c1c66c29d682023-12-09T06:07:04ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362023-12-0132101875An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodiumFritz Gerald P. Kalaw0Nathan L. Scott1Shyamanga Borooah2Jacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, USA; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, 92093, USA; Division of Ophthalmology Informatics and Data Science, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, 92093, USAJacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, USA; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, 92093, USAJacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, USA; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, 92093, USA; Corresponding author. Division of Retina, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego 9415 Campus Point Dr, La Jolla, CA, 92093, USA.Purpose: To report the structural and functional changes in a 67-year-old male with pentosan polysulfate sodium (PPS) maculopathy with a progressive resolution of bilateral vitelliform lesions after PPS cessation. Observations: The patient was initially seen after taking daily PPS for over 26 years. Three months after discontinuing PPS, the bilateral vitelliform lesions identified on spectral-domain optical coherence tomography (SD-OCT) at initial consultation had completely resolved. Bilateral resolution of vitelliform lesions was associated with a decline in best-corrected visual acuity, and ellipsoid zone disruption on SD-OCT. Conclusions and importance: Several PPS maculopathy phenotypes have been previously described including vitelliform lesions. Our case highlights that discontinuing PPS may lead to rapid resolution of vitelliform lesions in PPS maculopathy and may be associated with a rapid reduction in vision.http://www.sciencedirect.com/science/article/pii/S245199362300083XEllipsoid zone lossPentosan polysulfate sodium maculopathyPseudovitelliform lesionRetinal pigment epitheliumRetinal toxicity |
| spellingShingle | Fritz Gerald P. Kalaw Nathan L. Scott Shyamanga Borooah An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium American Journal of Ophthalmology Case Reports Ellipsoid zone loss Pentosan polysulfate sodium maculopathy Pseudovitelliform lesion Retinal pigment epithelium Retinal toxicity |
| title | An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium |
| title_full | An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium |
| title_fullStr | An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium |
| title_full_unstemmed | An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium |
| title_short | An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium |
| title_sort | unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium |
| topic | Ellipsoid zone loss Pentosan polysulfate sodium maculopathy Pseudovitelliform lesion Retinal pigment epithelium Retinal toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S245199362300083X |
| work_keys_str_mv | AT fritzgeraldpkalaw anunusualcaseofrapidresolutionofbilateralvitelliformdepositsafterdiscontinuationofpentosanpolysulfatesodium AT nathanlscott anunusualcaseofrapidresolutionofbilateralvitelliformdepositsafterdiscontinuationofpentosanpolysulfatesodium AT shyamangaborooah anunusualcaseofrapidresolutionofbilateralvitelliformdepositsafterdiscontinuationofpentosanpolysulfatesodium AT fritzgeraldpkalaw unusualcaseofrapidresolutionofbilateralvitelliformdepositsafterdiscontinuationofpentosanpolysulfatesodium AT nathanlscott unusualcaseofrapidresolutionofbilateralvitelliformdepositsafterdiscontinuationofpentosanpolysulfatesodium AT shyamangaborooah unusualcaseofrapidresolutionofbilateralvitelliformdepositsafterdiscontinuationofpentosanpolysulfatesodium |