3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione
Thiazolidine-2,4-dione core is widely used in the medicinal chemistry of different types of potential drug-like small molecules. In the present work, the synthesis of a novel non-condensed thiazolidine-2,4-dione-bearing derivative is reported by the two-step cost-effective approach including alkylat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2022/3/M1394 |
| _version_ | 1797484417290076160 |
|---|---|
| author | Serhii Holota Ihor Yushyn Andrzej Gzella Roman Lesyk |
| author_facet | Serhii Holota Ihor Yushyn Andrzej Gzella Roman Lesyk |
| author_sort | Serhii Holota |
| collection | DOAJ |
| description | Thiazolidine-2,4-dione core is widely used in the medicinal chemistry of different types of potential drug-like small molecules. In the present work, the synthesis of a novel non-condensed thiazolidine-2,4-dione-bearing derivative is reported by the two-step cost-effective approach including alkylation and Knoevenagel condensation. The structure of the synthesized 3-(2-diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione was determined and characterized using <sup>1</sup>H, <sup>13</sup>C NMR, LC-MS spectra and the X-ray diffraction method. |
| first_indexed | 2024-03-09T23:03:49Z |
| format | Article |
| id | doaj.art-421a5a5b5b2f4f18a856978399b70257 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-09T23:03:49Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-421a5a5b5b2f4f18a856978399b702572023-11-23T17:57:09ZengMDPI AGMolbank1422-85992022-06-0120223M139410.3390/M13943-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dioneSerhii Holota0Ihor Yushyn1Andrzej Gzella2Roman Lesyk3Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, PolandDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineThiazolidine-2,4-dione core is widely used in the medicinal chemistry of different types of potential drug-like small molecules. In the present work, the synthesis of a novel non-condensed thiazolidine-2,4-dione-bearing derivative is reported by the two-step cost-effective approach including alkylation and Knoevenagel condensation. The structure of the synthesized 3-(2-diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione was determined and characterized using <sup>1</sup>H, <sup>13</sup>C NMR, LC-MS spectra and the X-ray diffraction method.https://www.mdpi.com/1422-8599/2022/3/M1394thiazolidine-2,4-dionealkylationKnoevenagel condensationcost-effective approachX-ray diffraction |
| spellingShingle | Serhii Holota Ihor Yushyn Andrzej Gzella Roman Lesyk 3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione Molbank thiazolidine-2,4-dione alkylation Knoevenagel condensation cost-effective approach X-ray diffraction |
| title | 3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione |
| title_full | 3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione |
| title_fullStr | 3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione |
| title_full_unstemmed | 3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione |
| title_short | 3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione |
| title_sort | 3 2 diisopropylaminoethyl 5 4 methoxybenzylidene thiazolidine 2 4 dione |
| topic | thiazolidine-2,4-dione alkylation Knoevenagel condensation cost-effective approach X-ray diffraction |
| url | https://www.mdpi.com/1422-8599/2022/3/M1394 |
| work_keys_str_mv | AT serhiiholota 32diisopropylaminoethyl54methoxybenzylidenethiazolidine24dione AT ihoryushyn 32diisopropylaminoethyl54methoxybenzylidenethiazolidine24dione AT andrzejgzella 32diisopropylaminoethyl54methoxybenzylidenethiazolidine24dione AT romanlesyk 32diisopropylaminoethyl54methoxybenzylidenethiazolidine24dione |