Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection
Identification of host antiviral restriction factors could provide targets for antiviral therapy. Here, using a genome-wide CRISPR screen, the authors identify the glycosyltransferase B3GAT1 as a host protein which, when ectopically overexpressed, restricts influenza virus infection in vitro and in...
Main Authors: | Joseph D. Trimarco, Sarah L. Nelson, Ryan R. Chaparian, Alexandra I. Wells, Nathan B. Murray, Parastoo Azadi, Carolyn B. Coyne, Nicholas S. Heaton |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34111-0 |
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