F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway

F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway

Hepatic fibrosis (HF) is a precursor of liver cirrhosis, and activated hepatic stellate cells are an important driver of fibrosis. F-box and WD repeat domain containing 7 (FBXW7) expression level is down-regulated in HF, but the underlying mechanism is yet to be elucidated. The interaction between F...

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Bibliographic Details
Main Authors: Sun Yufeng, He Lili, Guo Peiran, Li Fenghua, Wang Bo, Zhang Yifan, An Kai, Peng Ming
Format: Article
Language:English
Published: De Gruyter 2023-04-01
Series:Open Medicine
Subjects:
hepatic fibrosis
lx-2 cells
delta-like ligand 1
ubiquitination
f-box and wd repeat domain containing 7
Online Access:https://doi.org/10.1515/med-2023-0634

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