Results of candidemia treatment in children with hematologic malignancies: single center experience
Candidemia is one of the most serious infectious complications in children with hematological malignancies and has a high morta lity rate.Seven-year experience of candidemia diagnosis and therapy in patients with various hematologic malignancies w as analyzed. Candidemia registered in 37 patients (A...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/87 |
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| author | I. I. Kalinina D. D. Baydildina E. V. Suntsova O. V. Goronkova L. A. Khachatryan U. N. Petrova G. G. Solopova V. V. Sinitsina G. A. Novichkova M. A. Maschan D. V. Litvinov N. V. Myakova G. A. Klyasova A. A. Maschan |
| author_facet | I. I. Kalinina D. D. Baydildina E. V. Suntsova O. V. Goronkova L. A. Khachatryan U. N. Petrova G. G. Solopova V. V. Sinitsina G. A. Novichkova M. A. Maschan D. V. Litvinov N. V. Myakova G. A. Klyasova A. A. Maschan |
| author_sort | I. I. Kalinina |
| collection | DOAJ |
| description | Candidemia is one of the most serious infectious complications in children with hematological malignancies and has a high morta lity rate.Seven-year experience of candidemia diagnosis and therapy in patients with various hematologic malignancies w as analyzed. Candidemia registered in 37 patients (AML and MDS — 14, ALL — 10, solid tumors — 5, histocytic syndromes — 4, AA — 3, other non-malignancy diseases— 2). C. non-albicans (36 isolates from 32 patients) was common cause of, while C. albicans isolated in 5 patients (8 strains). Antifungal prophylactic therapy was applied to 31 patients. 22 patients at the time of candidemia have neutropenia (< 0.5 × 10 9/l). Main clinical manifestations were febrile fever (100 % cases) and pneumonia (21.6 % cases). Less frequent multiorgan failure (8.1 %), septic shoc k (5.4 %), chronic disseminated candidiasis (5.4 %) and meningitis (2.7 %) were registered. All patients received antifungal therapy (monotherapy — 17, combination therapy — 20). Central venous catheter removed in 21 patients. In 14 patients hematopoietic recovery w as registered, none of these patients died, while from group of patients without hematopoietic recovery 6 patients died (p = 0.0001). Recurrent candidemia episodes were seen in 4 patients. Overall survival was 0.37 ± 0.09. |
| first_indexed | 2024-04-09T20:25:18Z |
| format | Article |
| id | doaj.art-421dc41acc7a4544a131c289e6c720ee |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:25:18Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-421dc41acc7a4544a131c289e6c720ee2023-03-30T20:15:10ZrusABV-pressОнкогематология1818-83462413-40232014-07-0163243410.17650/1818-8346-2011-6-3-24-34102Results of candidemia treatment in children with hematologic malignancies: single center experienceI. I. Kalinina0D. D. Baydildina1E. V. Suntsova2O. V. Goronkova3L. A. Khachatryan4U. N. Petrova5G. G. Solopova6V. V. Sinitsina7G. A. Novichkova8M. A. Maschan9D. V. Litvinov10N. V. Myakova11G. A. Klyasova12A. A. Maschan13Federal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyRussian Children Clinical HospitalFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and ImmunologyFederal Research Center of Children Hematology, Oncology and Immunology Russian Children Clinical HospitalFederal Research Center of Children Hematology, Oncology and Immunology Russian Children Clinical HospitalRussian Hematological Research CenterFederal Research Center of Children Hematology, Oncology and ImmunologyCandidemia is one of the most serious infectious complications in children with hematological malignancies and has a high morta lity rate.Seven-year experience of candidemia diagnosis and therapy in patients with various hematologic malignancies w as analyzed. Candidemia registered in 37 patients (AML and MDS — 14, ALL — 10, solid tumors — 5, histocytic syndromes — 4, AA — 3, other non-malignancy diseases— 2). C. non-albicans (36 isolates from 32 patients) was common cause of, while C. albicans isolated in 5 patients (8 strains). Antifungal prophylactic therapy was applied to 31 patients. 22 patients at the time of candidemia have neutropenia (< 0.5 × 10 9/l). Main clinical manifestations were febrile fever (100 % cases) and pneumonia (21.6 % cases). Less frequent multiorgan failure (8.1 %), septic shoc k (5.4 %), chronic disseminated candidiasis (5.4 %) and meningitis (2.7 %) were registered. All patients received antifungal therapy (monotherapy — 17, combination therapy — 20). Central venous catheter removed in 21 patients. In 14 patients hematopoietic recovery w as registered, none of these patients died, while from group of patients without hematopoietic recovery 6 patients died (p = 0.0001). Recurrent candidemia episodes were seen in 4 patients. Overall survival was 0.37 ± 0.09.https://oncohematology.abvpress.ru/ongm/article/view/87candidemiaantifungal prophylaxis and therapychildrenneutropenia |
| spellingShingle | I. I. Kalinina D. D. Baydildina E. V. Suntsova O. V. Goronkova L. A. Khachatryan U. N. Petrova G. G. Solopova V. V. Sinitsina G. A. Novichkova M. A. Maschan D. V. Litvinov N. V. Myakova G. A. Klyasova A. A. Maschan Results of candidemia treatment in children with hematologic malignancies: single center experience Онкогематология candidemia antifungal prophylaxis and therapy children neutropenia |
| title | Results of candidemia treatment in children with hematologic malignancies: single center experience |
| title_full | Results of candidemia treatment in children with hematologic malignancies: single center experience |
| title_fullStr | Results of candidemia treatment in children with hematologic malignancies: single center experience |
| title_full_unstemmed | Results of candidemia treatment in children with hematologic malignancies: single center experience |
| title_short | Results of candidemia treatment in children with hematologic malignancies: single center experience |
| title_sort | results of candidemia treatment in children with hematologic malignancies single center experience |
| topic | candidemia antifungal prophylaxis and therapy children neutropenia |
| url | https://oncohematology.abvpress.ru/ongm/article/view/87 |
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