Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs. In the past decade, human organ-on-a-chip (OO...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/11/11/456 |
| _version_ | 1827677157093015552 |
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| author | Shuang Ding Haijun Zhang Xuemei Wang |
| author_facet | Shuang Ding Haijun Zhang Xuemei Wang |
| author_sort | Shuang Ding |
| collection | DOAJ |
| description | Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs. In the past decade, human organ-on-a-chip (OOC) platforms—including lung-on-a-chip (LOC)—have emerged rapidly, with the ability to reproduce the in vivo features of organs or tissues based on their three-dimensional (3D) structures. Furthermore, the integration of biosensors in the chip allows researchers to monitor various parameters related to disease development and drug efficacy. In this review, we illustrate the biosensor-based LOC modeling, further discussing the future challenges as well as perspectives in integrating biosensors in OOC platforms. |
| first_indexed | 2024-03-10T05:40:09Z |
| format | Article |
| id | doaj.art-421e8c23c4bc42b89a793bf825a0372e |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T05:40:09Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-421e8c23c4bc42b89a793bf825a0372e2023-11-22T22:36:26ZengMDPI AGBiosensors2079-63742021-11-01111145610.3390/bios11110456Microfluidic-Chip-Integrated Biosensors for Lung Disease ModelsShuang Ding0Haijun Zhang1Xuemei Wang2Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, ChinaState Key Laboratory of Bioelectronics, School of Biomedical Engineering, Southeast University, Nanjing 210096, ChinaLung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs. In the past decade, human organ-on-a-chip (OOC) platforms—including lung-on-a-chip (LOC)—have emerged rapidly, with the ability to reproduce the in vivo features of organs or tissues based on their three-dimensional (3D) structures. Furthermore, the integration of biosensors in the chip allows researchers to monitor various parameters related to disease development and drug efficacy. In this review, we illustrate the biosensor-based LOC modeling, further discussing the future challenges as well as perspectives in integrating biosensors in OOC platforms.https://www.mdpi.com/2079-6374/11/11/456biosensormicrofluidicsorgan-on-a-chiplung modellung-on-a-chip |
| spellingShingle | Shuang Ding Haijun Zhang Xuemei Wang Microfluidic-Chip-Integrated Biosensors for Lung Disease Models Biosensors biosensor microfluidics organ-on-a-chip lung model lung-on-a-chip |
| title | Microfluidic-Chip-Integrated Biosensors for Lung Disease Models |
| title_full | Microfluidic-Chip-Integrated Biosensors for Lung Disease Models |
| title_fullStr | Microfluidic-Chip-Integrated Biosensors for Lung Disease Models |
| title_full_unstemmed | Microfluidic-Chip-Integrated Biosensors for Lung Disease Models |
| title_short | Microfluidic-Chip-Integrated Biosensors for Lung Disease Models |
| title_sort | microfluidic chip integrated biosensors for lung disease models |
| topic | biosensor microfluidics organ-on-a-chip lung model lung-on-a-chip |
| url | https://www.mdpi.com/2079-6374/11/11/456 |
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