Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors

Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors

Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis. In addition, MUC1 overexpression is closely interrelated with angiogenesis, making it a great t...

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Bibliographic Details
Main Authors: Parnaz Merikhian, Behrad Darvishi, Neda Jalili, Mohammad Reza Esmailinejad, Azadeh Sharif Khatibi, Shima Moradi Kalbolandi, Malihe Salehi, Marjan Mosayebzadeh, Mahdieh Shokrollahi Barough, Keivan Majidzadeh‐A, Fatemeh Yadegari, Fatemeh Rahbarizadeh, Leila Farahmand
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Molecular Oncology
Subjects:
angiogenesis
cancers
invasion and metastasis
MUC1
nanobody
tumor growth
Online Access:https://doi.org/10.1002/1878-0261.13123

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