Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens
Species of the family Bufonidae, better known as true toads, are widespread and produce bioactive substances in the secretions obtained from specialized skin macroglands. Some true toads have been employed as a folk remedy to treat infectious diseases caused by microbial pathogens. Recent publicatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/12/843 |
| _version_ | 1797546764637569024 |
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| author | Candelario Rodriguez Roberto Ibáñez Louise A. Rollins-Smith Marcelino Gutiérrez Armando A. Durant-Archibold |
| author_facet | Candelario Rodriguez Roberto Ibáñez Louise A. Rollins-Smith Marcelino Gutiérrez Armando A. Durant-Archibold |
| author_sort | Candelario Rodriguez |
| collection | DOAJ |
| description | Species of the family Bufonidae, better known as true toads, are widespread and produce bioactive substances in the secretions obtained from specialized skin macroglands. Some true toads have been employed as a folk remedy to treat infectious diseases caused by microbial pathogens. Recent publications based on in silico analysis highlighted the Bufonidae as promising sources of antimicrobial peptides. A review of the literature reveals that Bufonidae skin secretion extracts show inhibitory activity in vitro against clinical isolates of bacteria, resistant and standard strains of bacterial, and fungal and parasitic human pathogens. Secondary metabolites belonging to the classes of alkaloids, bufadienolides, and peptides with antimicrobial activity have been isolated from species of the genera <i>Bufo</i>, <i>Bufotes</i>, <i>Duttaphrynus,</i> and <i>Rhinella</i>. Additionally, some antimicrobial extracts and purified compounds display low cytotoxicity against mammal cells. |
| first_indexed | 2024-03-10T14:33:51Z |
| format | Article |
| id | doaj.art-42214ce60153416dba8ec8395adf9220 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T14:33:51Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-42214ce60153416dba8ec8395adf92202023-11-20T22:21:40ZengMDPI AGAntibiotics2079-63822020-11-0191284310.3390/antibiotics9120843Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human PathogensCandelario Rodriguez0Roberto Ibáñez1Louise A. Rollins-Smith2Marcelino Gutiérrez3Armando A. Durant-Archibold4Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, Panama City 0843-01103, PanamaSmithsonian Tropical Research Institute (STRI), Balboa 0843-03092, PanamaDepartment of Pathology, Microbiology, and Immunology, and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USACentro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, Panama City 0843-01103, PanamaCentro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, Panama City 0843-01103, PanamaSpecies of the family Bufonidae, better known as true toads, are widespread and produce bioactive substances in the secretions obtained from specialized skin macroglands. Some true toads have been employed as a folk remedy to treat infectious diseases caused by microbial pathogens. Recent publications based on in silico analysis highlighted the Bufonidae as promising sources of antimicrobial peptides. A review of the literature reveals that Bufonidae skin secretion extracts show inhibitory activity in vitro against clinical isolates of bacteria, resistant and standard strains of bacterial, and fungal and parasitic human pathogens. Secondary metabolites belonging to the classes of alkaloids, bufadienolides, and peptides with antimicrobial activity have been isolated from species of the genera <i>Bufo</i>, <i>Bufotes</i>, <i>Duttaphrynus,</i> and <i>Rhinella</i>. Additionally, some antimicrobial extracts and purified compounds display low cytotoxicity against mammal cells.https://www.mdpi.com/2079-6382/9/12/843alkaloidsamphibiansantimicrobial peptidesbufadienolidesBufonidaecrude extract |
| spellingShingle | Candelario Rodriguez Roberto Ibáñez Louise A. Rollins-Smith Marcelino Gutiérrez Armando A. Durant-Archibold Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens Antibiotics alkaloids amphibians antimicrobial peptides bufadienolides Bufonidae crude extract |
| title | Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens |
| title_full | Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens |
| title_fullStr | Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens |
| title_full_unstemmed | Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens |
| title_short | Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens |
| title_sort | antimicrobial secretions of toads anura bufonidae bioactive extracts and isolated compounds against human pathogens |
| topic | alkaloids amphibians antimicrobial peptides bufadienolides Bufonidae crude extract |
| url | https://www.mdpi.com/2079-6382/9/12/843 |
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