Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz
Neural activity exhibits oscillations, bursts, and resonance, enhancing responsiveness at preferential frequencies. For example, theta-frequency bursting and resonance in granule cells facilitate synaptic transmission and plasticity mechanisms at the input stage of the cerebellar cortex. However, wh...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1831 |
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| author | Staf Bauer Nathalie van Wingerden Thomas Jacobs Annabel van der Horst Peipei Zhai Jan-Harm L. F. Betting Christos Strydis Joshua J. White Chris I. De Zeeuw Vincenzo Romano |
| author_facet | Staf Bauer Nathalie van Wingerden Thomas Jacobs Annabel van der Horst Peipei Zhai Jan-Harm L. F. Betting Christos Strydis Joshua J. White Chris I. De Zeeuw Vincenzo Romano |
| author_sort | Staf Bauer |
| collection | DOAJ |
| description | Neural activity exhibits oscillations, bursts, and resonance, enhancing responsiveness at preferential frequencies. For example, theta-frequency bursting and resonance in granule cells facilitate synaptic transmission and plasticity mechanisms at the input stage of the cerebellar cortex. However, whether theta-frequency bursting of Purkinje cells is involved in generating rhythmic behavior has remained neglected. We recorded and optogenetically modulated the simple and complex spike activity of Purkinje cells while monitoring whisker movements with a high-speed camera of awake, head-fixed mice. During spontaneous whisking, both simple spike activity and whisker movement exhibit peaks within the theta band. Eliciting either simple or complex spikes at frequencies ranging from 0.5 to 28 Hz, we found that 8 Hz is the preferred frequency around which the largest movement is induced. Interestingly, oscillatory whisker movements at 8 Hz were also generated when simple spike bursting was induced at 2 and 4 Hz, but never via climbing fiber stimulation. These results indicate that 8 Hz is the resonant frequency at which the cerebellar-whisker circuitry produces rhythmic whisking. |
| first_indexed | 2024-03-09T11:51:21Z |
| format | Article |
| id | doaj.art-42216e8ad05a40b7b1b1bd737087a212 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:51:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-42216e8ad05a40b7b1b1bd737087a2122023-11-30T23:14:22ZengMDPI AGBiomedicines2227-90592022-07-01108183110.3390/biomedicines10081831Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 HzStaf Bauer0Nathalie van Wingerden1Thomas Jacobs2Annabel van der Horst3Peipei Zhai4Jan-Harm L. F. Betting5Christos Strydis6Joshua J. White7Chris I. De Zeeuw8Vincenzo Romano9Department of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsDepartment of Neuroscience, Erasmus MC, 3015 GD Rotterdam, The NetherlandsNeural activity exhibits oscillations, bursts, and resonance, enhancing responsiveness at preferential frequencies. For example, theta-frequency bursting and resonance in granule cells facilitate synaptic transmission and plasticity mechanisms at the input stage of the cerebellar cortex. However, whether theta-frequency bursting of Purkinje cells is involved in generating rhythmic behavior has remained neglected. We recorded and optogenetically modulated the simple and complex spike activity of Purkinje cells while monitoring whisker movements with a high-speed camera of awake, head-fixed mice. During spontaneous whisking, both simple spike activity and whisker movement exhibit peaks within the theta band. Eliciting either simple or complex spikes at frequencies ranging from 0.5 to 28 Hz, we found that 8 Hz is the preferred frequency around which the largest movement is induced. Interestingly, oscillatory whisker movements at 8 Hz were also generated when simple spike bursting was induced at 2 and 4 Hz, but never via climbing fiber stimulation. These results indicate that 8 Hz is the resonant frequency at which the cerebellar-whisker circuitry produces rhythmic whisking.https://www.mdpi.com/2227-9059/10/8/1831Purkinje cellcerebellumtheta resonancewhiskeroptogenetics stimulation |
| spellingShingle | Staf Bauer Nathalie van Wingerden Thomas Jacobs Annabel van der Horst Peipei Zhai Jan-Harm L. F. Betting Christos Strydis Joshua J. White Chris I. De Zeeuw Vincenzo Romano Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz Biomedicines Purkinje cell cerebellum theta resonance whisker optogenetics stimulation |
| title | Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz |
| title_full | Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz |
| title_fullStr | Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz |
| title_full_unstemmed | Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz |
| title_short | Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz |
| title_sort | purkinje cell activity resonation generates rhythmic behaviors at the preferred frequency of 8 hz |
| topic | Purkinje cell cerebellum theta resonance whisker optogenetics stimulation |
| url | https://www.mdpi.com/2227-9059/10/8/1831 |
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