Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy
Dietary polyphenols gained the interest of the scientific community due to their wide content in a variety of plant-derived foods and beverages commonly consumed, such as fruits, vegetables, coffee, tea, and cocoa. We aimed to investigate whether there was an association between dietary phenolic aci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/22/12/2159 |
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| author | Giorgio Ivan Russo Daniele Campisi Marina Di Mauro Federica Regis Giulio Reale Marina Marranzano Rosalia Ragusa Tatiana Solinas Massimo Madonia Sebastiano Cimino Giuseppe Morgia |
| author_facet | Giorgio Ivan Russo Daniele Campisi Marina Di Mauro Federica Regis Giulio Reale Marina Marranzano Rosalia Ragusa Tatiana Solinas Massimo Madonia Sebastiano Cimino Giuseppe Morgia |
| author_sort | Giorgio Ivan Russo |
| collection | DOAJ |
| description | Dietary polyphenols gained the interest of the scientific community due to their wide content in a variety of plant-derived foods and beverages commonly consumed, such as fruits, vegetables, coffee, tea, and cocoa. We aimed to investigate whether there was an association between dietary phenolic acid consumption and prostate cancer (PCa) in South Italy. We conducted a population-based case-control study from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). Patients with elevated PSA and/or suspicious PCa underwent transperineal prostate biopsy. A total of 118 histopathological-verified PCa cases were collected and a total of 222 controls were selected from a sample of 2044 individuals. Dietary data were collected by using two food frequency questionnaires and data on the phenolic acids content in foods was obtained from the Phenol-Explorer database (www.phenol-explorer.eu). Association between dietary intake of phenolic acids and PCa was calculated through logistic regression analysis. We found lower levels of caffeic acid (2.28 mg/day vs. 2.76 mg/day; p < 0.05) and ferulic acid (2.80 mg/day vs. 4.04 mg/day; p < 0.01) in PCa when compared to controls. The multivariate logistic regression showed that both caffeic acid (OR = 0.32; p < 0.05) and ferulic acid (OR = 0.30; p < 0.05) were associated with reduced risk of PCa. Higher intake of hydroxybenzoic acids and caffeic acids were associated with lower risk of advanced PCa. High intake of caffeic acid and ferulic acid may be associated with reduced risk of PCa. |
| first_indexed | 2024-04-12T00:31:56Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T00:31:56Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-42227f0050324e699d89e4f0066812572022-12-22T03:55:18ZengMDPI AGMolecules1420-30492017-12-012212215910.3390/molecules22122159molecules22122159Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern ItalyGiorgio Ivan Russo0Daniele Campisi1Marina Di Mauro2Federica Regis3Giulio Reale4Marina Marranzano5Rosalia Ragusa6Tatiana Solinas7Massimo Madonia8Sebastiano Cimino9Giuseppe Morgia10Urology Section, University of Catania, 95124 Catania, ItalyUrology Section, University of Catania, 95124 Catania, ItalyUrology Section, University of Catania, 95124 Catania, ItalyUrology Section, University of Catania, 95124 Catania, ItalyUrology Section, University of Catania, 95124 Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Section of Hygiene and Preventive Medicine, University of Catania, 95124 Catania, ItalyHealth Direction of Policlinic Hospital, 95100 Catania, ItalyUrology Section, University of Sassari, 07100 Sassari, ItalyUrology Section, University of Sassari, 07100 Sassari, ItalyUrology Section, University of Catania, 95124 Catania, ItalyUrology Section, University of Catania, 95124 Catania, ItalyDietary polyphenols gained the interest of the scientific community due to their wide content in a variety of plant-derived foods and beverages commonly consumed, such as fruits, vegetables, coffee, tea, and cocoa. We aimed to investigate whether there was an association between dietary phenolic acid consumption and prostate cancer (PCa) in South Italy. We conducted a population-based case-control study from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). Patients with elevated PSA and/or suspicious PCa underwent transperineal prostate biopsy. A total of 118 histopathological-verified PCa cases were collected and a total of 222 controls were selected from a sample of 2044 individuals. Dietary data were collected by using two food frequency questionnaires and data on the phenolic acids content in foods was obtained from the Phenol-Explorer database (www.phenol-explorer.eu). Association between dietary intake of phenolic acids and PCa was calculated through logistic regression analysis. We found lower levels of caffeic acid (2.28 mg/day vs. 2.76 mg/day; p < 0.05) and ferulic acid (2.80 mg/day vs. 4.04 mg/day; p < 0.01) in PCa when compared to controls. The multivariate logistic regression showed that both caffeic acid (OR = 0.32; p < 0.05) and ferulic acid (OR = 0.30; p < 0.05) were associated with reduced risk of PCa. Higher intake of hydroxybenzoic acids and caffeic acids were associated with lower risk of advanced PCa. High intake of caffeic acid and ferulic acid may be associated with reduced risk of PCa.https://www.mdpi.com/1420-3049/22/12/2159dietMediterranean dietphenolic acidsprostate cancerrisk factors |
| spellingShingle | Giorgio Ivan Russo Daniele Campisi Marina Di Mauro Federica Regis Giulio Reale Marina Marranzano Rosalia Ragusa Tatiana Solinas Massimo Madonia Sebastiano Cimino Giuseppe Morgia Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy Molecules diet Mediterranean diet phenolic acids prostate cancer risk factors |
| title | Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy |
| title_full | Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy |
| title_fullStr | Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy |
| title_full_unstemmed | Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy |
| title_short | Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy |
| title_sort | dietary consumption of phenolic acids and prostate cancer a case control study in sicily southern italy |
| topic | diet Mediterranean diet phenolic acids prostate cancer risk factors |
| url | https://www.mdpi.com/1420-3049/22/12/2159 |
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