Malaria vaccines: lessons from field trials
Malaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
1994-01-01
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| Series: | Cadernos de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1994000800009 |
| _version_ | 1818516871093157888 |
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| author | Struchiner Claudio J. Halloran M. Elizabeth Brunet Robert C. Ribeiro José M. C. Massad Eduardo |
| author_facet | Struchiner Claudio J. Halloran M. Elizabeth Brunet Robert C. Ribeiro José M. C. Massad Eduardo |
| author_sort | Struchiner Claudio J. |
| collection | DOAJ |
| description | Malaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretation of the data being gathered in actual malaria vaccine field trials. Our discussion assumes that vaccine evaluation shares the same general principles of validity with epidemiologic causal inference, i.e., the process of drawing inferences from epidemiologic data aiming at the identification of causes of diseases. Judicious exercise of these principles indicates that, for meaningful interpretation, measures of vaccine efficacy require definitions based upon arguments conditional on the amount of exposure to infection, and specification of the initial and final states in which one believes the effect of interest takes place. |
| first_indexed | 2024-12-11T00:48:16Z |
| format | Article |
| id | doaj.art-422303df86f34e249fbaa996b919e1f2 |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-12-11T00:48:16Z |
| publishDate | 1994-01-01 |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-422303df86f34e249fbaa996b919e1f22022-12-22T01:26:42ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44641994-01-0110suppl.2310326Malaria vaccines: lessons from field trialsStruchiner Claudio J.Halloran M. ElizabethBrunet Robert C.Ribeiro José M. C.Massad EduardoMalaria vaccine candidates have already been tested and new trials are being carried out. We present a brief description of specific issues of validity that are relevant when assessing vaccine efficacy in the field and illustrate how the application of these principles might improve our interpretation of the data being gathered in actual malaria vaccine field trials. Our discussion assumes that vaccine evaluation shares the same general principles of validity with epidemiologic causal inference, i.e., the process of drawing inferences from epidemiologic data aiming at the identification of causes of diseases. Judicious exercise of these principles indicates that, for meaningful interpretation, measures of vaccine efficacy require definitions based upon arguments conditional on the amount of exposure to infection, and specification of the initial and final states in which one believes the effect of interest takes place.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1994000800009MalariaVaccineVaccine EfficacyField Trial |
| spellingShingle | Struchiner Claudio J. Halloran M. Elizabeth Brunet Robert C. Ribeiro José M. C. Massad Eduardo Malaria vaccines: lessons from field trials Cadernos de Saúde Pública Malaria Vaccine Vaccine Efficacy Field Trial |
| title | Malaria vaccines: lessons from field trials |
| title_full | Malaria vaccines: lessons from field trials |
| title_fullStr | Malaria vaccines: lessons from field trials |
| title_full_unstemmed | Malaria vaccines: lessons from field trials |
| title_short | Malaria vaccines: lessons from field trials |
| title_sort | malaria vaccines lessons from field trials |
| topic | Malaria Vaccine Vaccine Efficacy Field Trial |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1994000800009 |
| work_keys_str_mv | AT struchinerclaudioj malariavaccineslessonsfromfieldtrials AT halloranmelizabeth malariavaccineslessonsfromfieldtrials AT brunetrobertc malariavaccineslessonsfromfieldtrials AT ribeirojosemc malariavaccineslessonsfromfieldtrials AT massadeduardo malariavaccineslessonsfromfieldtrials |