Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction
Background: Androgens have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (EF).Methods: The study population consisted of 515 consecutive men who were refer...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2010-08-01
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| Series: | Journal of Tehran University Heart Center |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16128.pdf&manuscript_id=16128 |
| _version_ | 1819229680487628800 |
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| author | Maryam Sotoudeh Anvari Mehrnaz Rezvanfard Ahmad Yamini Sharif Ali Kazemi Saeid Maria Raissi Dehkordi Mohammad Ali Boroumand Alireza Amirzadegan Gholamreza Davoodi |
| author_facet | Maryam Sotoudeh Anvari Mehrnaz Rezvanfard Ahmad Yamini Sharif Ali Kazemi Saeid Maria Raissi Dehkordi Mohammad Ali Boroumand Alireza Amirzadegan Gholamreza Davoodi |
| author_sort | Maryam Sotoudeh Anvari |
| collection | DOAJ |
| description | Background: Androgens have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (EF).Methods: The study population consisted of 515 consecutive men who were referred for angiographic studies and whose results of echocardiography and coronary angiography were available. The patients were classified into four groups: EF < 35%, EF = 35-45%, EF = 45-54%, and EF ≥ 55% to evaluate the trends of baseline characteristics and serum androgens,including free testosterone (fT), total testosterone (tT), and dehydroepiandrosterone sulfate (DHEAS). To better elucidate thedifference in the patients with severe heart failure, the patients were divided into two groups according to their EF level, andcomparisons were repeated between those with EF < 35% and the ones with EF ≥ 35%.Results: There were statistically significant trends in some characteristics in the patients with different levels of EF. The subjects with higher EF levels were less likely to have diabetes (p value < 0.001), coronary artery lesion (p value < 0.001),or high levels of C-reactive protein (CRP) (p value < 0.001). As regards the patients with severe heart failure, our regressionanalysis revealed that the fT level was significantly lower in those with EF < 35% than in the ones with EF ≥ 35% (5.82 ± 2.73 pg/mL vs. 6.88 ± 3.34 pg/mL, p value < 0.05).Conclusion: A significant association was found between the level of fT and EF < 35%. There is a need for further controlled prospective studies to delineate any possible causal relationship accurately. |
| first_indexed | 2024-12-23T11:17:01Z |
| format | Article |
| id | doaj.art-42240b903aaa4a6b9673f7bb1850f978 |
| institution | Directory Open Access Journal |
| issn | 1735-8620 |
| language | English |
| last_indexed | 2024-12-23T11:17:01Z |
| publishDate | 2010-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-42240b903aaa4a6b9673f7bb1850f9782022-12-21T17:49:11ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202010-08-0153141145Association between Androgenic Hormone Levels and Left Ventricular Ejection FractionMaryam Sotoudeh AnvariMehrnaz RezvanfardAhmad Yamini SharifAli Kazemi SaeidMaria Raissi DehkordiMohammad Ali BoroumandAlireza AmirzadeganGholamreza DavoodiBackground: Androgens have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (EF).Methods: The study population consisted of 515 consecutive men who were referred for angiographic studies and whose results of echocardiography and coronary angiography were available. The patients were classified into four groups: EF < 35%, EF = 35-45%, EF = 45-54%, and EF ≥ 55% to evaluate the trends of baseline characteristics and serum androgens,including free testosterone (fT), total testosterone (tT), and dehydroepiandrosterone sulfate (DHEAS). To better elucidate thedifference in the patients with severe heart failure, the patients were divided into two groups according to their EF level, andcomparisons were repeated between those with EF < 35% and the ones with EF ≥ 35%.Results: There were statistically significant trends in some characteristics in the patients with different levels of EF. The subjects with higher EF levels were less likely to have diabetes (p value < 0.001), coronary artery lesion (p value < 0.001),or high levels of C-reactive protein (CRP) (p value < 0.001). As regards the patients with severe heart failure, our regressionanalysis revealed that the fT level was significantly lower in those with EF < 35% than in the ones with EF ≥ 35% (5.82 ± 2.73 pg/mL vs. 6.88 ± 3.34 pg/mL, p value < 0.05).Conclusion: A significant association was found between the level of fT and EF < 35%. There is a need for further controlled prospective studies to delineate any possible causal relationship accurately.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16128.pdf&manuscript_id=16128TestosteroneAndrogensHeart FailureVentricular Function- Left |
| spellingShingle | Maryam Sotoudeh Anvari Mehrnaz Rezvanfard Ahmad Yamini Sharif Ali Kazemi Saeid Maria Raissi Dehkordi Mohammad Ali Boroumand Alireza Amirzadegan Gholamreza Davoodi Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction Journal of Tehran University Heart Center Testosterone Androgens Heart Failure Ventricular Function- Left |
| title | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_full | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_fullStr | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_full_unstemmed | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_short | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_sort | association between androgenic hormone levels and left ventricular ejection fraction |
| topic | Testosterone Androgens Heart Failure Ventricular Function- Left |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16128.pdf&manuscript_id=16128 |
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