Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases
Oxaliplatin, a third-generation platinum-based agent, is a constitutive part of systemic treatment for colorectal cancer in adjuvant and metastatic settings. Ocular toxicity is an extremely rare adverse effect of Oxaliplatin. Ocular toxicities have been documented in the form of (a) common (≥1/100,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-02-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/521842 |
| _version_ | 1818137745892048896 |
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| author | Mutahar Ali Tunio Karen Phillips Peter Baker |
| author_facet | Mutahar Ali Tunio Karen Phillips Peter Baker |
| author_sort | Mutahar Ali Tunio |
| collection | DOAJ |
| description | Oxaliplatin, a third-generation platinum-based agent, is a constitutive part of systemic treatment for colorectal cancer in adjuvant and metastatic settings. Ocular toxicity is an extremely rare adverse effect of Oxaliplatin. Ocular toxicities have been documented in the form of (a) common (≥1/100, <1/10) which include the conjunctivitis, unexpected lacrimation, blurry vision, blepharoptosis, and (b) uncommon (≥1/10,000, <1/1,000) which compromise the tunnel vision, idiosyncratic color perception, transient bilateral visual loss, and rarest phenomenon of Amaurosis fugax. Amaurosis fugax implies to any cause of transient, painless, unilateral visual loss; with the possible underlying mechanism of thrombo-embolic carotid plaque, hypoperfusion, or vasospasm of retinal vessels, due to hyperviscosity, and atherosclerotic vascular disease. To date, only a few case reports of Oxaliplatin-induced Amaurosis fugax have been published. We here-in report 3 cases who experienced Amaurosis fugax while receiving Oxaliplatin in our one of health board-based four hospitals. |
| first_indexed | 2024-12-11T10:01:11Z |
| format | Article |
| id | doaj.art-42261e26f7724db59455598ade45d771 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-11T10:01:11Z |
| publishDate | 2022-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-42261e26f7724db59455598ade45d7712022-12-22T01:12:07ZengKarger PublishersCase Reports in Oncology1662-65752022-02-0115113313710.1159/000521842521842Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three CasesMutahar Ali Tunio0https://orcid.org/0000-0002-6433-673XKaren Phillips1Peter Baker2Colorectal Division, Swansea Bay University Health Board, Swansea, United KingdomColorectal Division, Hywel Da University Health Board, Carmarthen, United KingdomClinical Pharmacy, Hywel Da University Health Board, Carmarthen, United KingdomOxaliplatin, a third-generation platinum-based agent, is a constitutive part of systemic treatment for colorectal cancer in adjuvant and metastatic settings. Ocular toxicity is an extremely rare adverse effect of Oxaliplatin. Ocular toxicities have been documented in the form of (a) common (≥1/100, <1/10) which include the conjunctivitis, unexpected lacrimation, blurry vision, blepharoptosis, and (b) uncommon (≥1/10,000, <1/1,000) which compromise the tunnel vision, idiosyncratic color perception, transient bilateral visual loss, and rarest phenomenon of Amaurosis fugax. Amaurosis fugax implies to any cause of transient, painless, unilateral visual loss; with the possible underlying mechanism of thrombo-embolic carotid plaque, hypoperfusion, or vasospasm of retinal vessels, due to hyperviscosity, and atherosclerotic vascular disease. To date, only a few case reports of Oxaliplatin-induced Amaurosis fugax have been published. We here-in report 3 cases who experienced Amaurosis fugax while receiving Oxaliplatin in our one of health board-based four hospitals.https://www.karger.com/Article/FullText/521842oxaliplatintoxicityocularamaurosis fugax |
| spellingShingle | Mutahar Ali Tunio Karen Phillips Peter Baker Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases Case Reports in Oncology oxaliplatin toxicity ocular amaurosis fugax |
| title | Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases |
| title_full | Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases |
| title_fullStr | Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases |
| title_full_unstemmed | Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases |
| title_short | Amaurosis Fugax: A Rare Oxaliplatin-Induced Ocular Toxicity – A Report of Three Cases |
| title_sort | amaurosis fugax a rare oxaliplatin induced ocular toxicity a report of three cases |
| topic | oxaliplatin toxicity ocular amaurosis fugax |
| url | https://www.karger.com/Article/FullText/521842 |
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