Lipoprotein (a): impact by ethnicity and environmental and medical conditions
Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-07-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752035149X |
| _version_ | 1818957301622505472 |
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| author | Byambaa Enkhmaa Erdembileg Anuurad Lars Berglund |
| author_facet | Byambaa Enkhmaa Erdembileg Anuurad Lars Berglund |
| author_sort | Byambaa Enkhmaa |
| collection | DOAJ |
| description | Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong predictor of plasma Lp(a) levels resulting in stable plasma levels across the lifespan. Studies have demonstrated pronounced differences across ethnicities with regard to Lp(a) levels and some of this difference, but not all of it, can be explained by genetic variations across ethnic groups. Increasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases. |
| first_indexed | 2024-12-20T11:07:41Z |
| format | Article |
| id | doaj.art-4226bce7016e4913ba0c4a7a32006733 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-20T11:07:41Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-4226bce7016e4913ba0c4a7a320067332022-12-21T19:42:50ZengElsevierJournal of Lipid Research0022-22752016-07-0157711111125Lipoprotein (a): impact by ethnicity and environmental and medical conditionsByambaa Enkhmaa0Erdembileg Anuurad1Lars Berglund2Department of Internal Medicine, University of California, Davis, CADepartment of Internal Medicine, University of California, Davis, CATo whom correspondence should be addressed; Department of Internal Medicine, University of California, Davis, CA; Veterans Affairs Northern California Health Care System, Sacramento, CA; To whom correspondence should be addressedLevels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong predictor of plasma Lp(a) levels resulting in stable plasma levels across the lifespan. Studies have demonstrated pronounced differences across ethnicities with regard to Lp(a) levels and some of this difference, but not all of it, can be explained by genetic variations across ethnic groups. Increasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases.http://www.sciencedirect.com/science/article/pii/S002222752035149Xpopulationsapolipoprotein (a) sizegeneticsdemographic and clinical characteristicskidney and liver diseasediabetes |
| spellingShingle | Byambaa Enkhmaa Erdembileg Anuurad Lars Berglund Lipoprotein (a): impact by ethnicity and environmental and medical conditions Journal of Lipid Research populations apolipoprotein (a) size genetics demographic and clinical characteristics kidney and liver disease diabetes |
| title | Lipoprotein (a): impact by ethnicity and environmental and medical conditions |
| title_full | Lipoprotein (a): impact by ethnicity and environmental and medical conditions |
| title_fullStr | Lipoprotein (a): impact by ethnicity and environmental and medical conditions |
| title_full_unstemmed | Lipoprotein (a): impact by ethnicity and environmental and medical conditions |
| title_short | Lipoprotein (a): impact by ethnicity and environmental and medical conditions |
| title_sort | lipoprotein a impact by ethnicity and environmental and medical conditions |
| topic | populations apolipoprotein (a) size genetics demographic and clinical characteristics kidney and liver disease diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S002222752035149X |
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