Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods
CONTEXT: HBV infection is endemic in Brazil and acute HBV infection is still a common disease. OBJECTIVE: To analyze incidence, risk factors and evolution of acute HBV infection. SETTING: University Hospital. PATIENTS: 357 patients with acute HBV infection, comparing two periods: 1985-1989 vs. 1990-...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801998000300002&lng=en&tlng=en |
| _version_ | 1819129983007719424 |
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| author | Maria Lúcia Gomes Ferraz Alessandra Yoradjian Andrea Barbieri Virginia Figueiredo Edmundo Lopes Neto Cibele Nascimento Cruz Antonio Eduardo Silva |
| author_facet | Maria Lúcia Gomes Ferraz Alessandra Yoradjian Andrea Barbieri Virginia Figueiredo Edmundo Lopes Neto Cibele Nascimento Cruz Antonio Eduardo Silva |
| author_sort | Maria Lúcia Gomes Ferraz |
| collection | DOAJ |
| description | CONTEXT: HBV infection is endemic in Brazil and acute HBV infection is still a common disease. OBJECTIVE: To analyze incidence, risk factors and evolution of acute HBV infection. SETTING: University Hospital. PATIENTS: 357 patients with acute HBV infection, comparing two periods: 1985-1989 vs. 1990-1994. RESULTS: The overall incidence declined from 50 new cases/year in 1985-89 (30% of all cases) to 25 new cases/year in 1990-94 (8% of all cases). Transmission among male homosexuals (3.9% of cases in 85-89) declined to 1.3% in 90-94 (p>0.05). Amongst health care workers (HCW) it declined from 8.2% to 2.0% (p=0.02). Conversely, heterosexual transmission increased from 4.8% to 10.1% (p=0.06). Chronification of HBV infection following the acute episode was observed in 1.7%. Fulminant hepatic failure was seen in 3.4%. However, 27.2% of patients were lost to follow-up before normalization of the biochemical tests. CONCLUSIONS: The different patterns of risk factors observed is probably related to measures for preventing AIDS and to HCW vaccination programs. Chronification following acute episodes was not a common event. |
| first_indexed | 2024-12-22T08:52:22Z |
| format | Article |
| id | doaj.art-422725a1e9eb44ee95f35e614a09d139 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-22T08:52:22Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-422725a1e9eb44ee95f35e614a09d1392022-12-21T18:31:55ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-946011631695169910.1590/S1516-31801998000300002S1516-31801998000300002Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periodsMaria Lúcia Gomes Ferraz0Alessandra Yoradjian1Andrea Barbieri2Virginia Figueiredo3Edmundo Lopes Neto4Cibele Nascimento Cruz5Antonio Eduardo Silva6Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloCONTEXT: HBV infection is endemic in Brazil and acute HBV infection is still a common disease. OBJECTIVE: To analyze incidence, risk factors and evolution of acute HBV infection. SETTING: University Hospital. PATIENTS: 357 patients with acute HBV infection, comparing two periods: 1985-1989 vs. 1990-1994. RESULTS: The overall incidence declined from 50 new cases/year in 1985-89 (30% of all cases) to 25 new cases/year in 1990-94 (8% of all cases). Transmission among male homosexuals (3.9% of cases in 85-89) declined to 1.3% in 90-94 (p>0.05). Amongst health care workers (HCW) it declined from 8.2% to 2.0% (p=0.02). Conversely, heterosexual transmission increased from 4.8% to 10.1% (p=0.06). Chronification of HBV infection following the acute episode was observed in 1.7%. Fulminant hepatic failure was seen in 3.4%. However, 27.2% of patients were lost to follow-up before normalization of the biochemical tests. CONCLUSIONS: The different patterns of risk factors observed is probably related to measures for preventing AIDS and to HCW vaccination programs. Chronification following acute episodes was not a common event.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801998000300002&lng=en&tlng=enHepatitisHepatitis BAcute hepatitis BEpidemiology |
| spellingShingle | Maria Lúcia Gomes Ferraz Alessandra Yoradjian Andrea Barbieri Virginia Figueiredo Edmundo Lopes Neto Cibele Nascimento Cruz Antonio Eduardo Silva Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods São Paulo Medical Journal Hepatitis Hepatitis B Acute hepatitis B Epidemiology |
| title | Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods |
| title_full | Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods |
| title_fullStr | Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods |
| title_full_unstemmed | Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods |
| title_short | Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods |
| title_sort | epidemiology of acute hepatitis b in a university hospital in sao paulo brazil retrospective study of two five year periods |
| topic | Hepatitis Hepatitis B Acute hepatitis B Epidemiology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801998000300002&lng=en&tlng=en |
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