Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program
Background: This pilot study explores a therapeutic setting combining transcranial direct current stimulation (tDCS) and mindfulness-based cognitive therapy (MBCT) for patients with drug-resistant depression. tDCS has shown efficacy for depression treatment and improvement could be maintained with t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-10-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00730/full |
| _version_ | 1818020226166423552 |
|---|---|
| author | Aurore Monnart Marie-Anne Vanderhasselt Marie-Anne Vanderhasselt Elisa Schroder Salvatore Campanella Philippe Fontaine Charles Kornreich |
| author_facet | Aurore Monnart Marie-Anne Vanderhasselt Marie-Anne Vanderhasselt Elisa Schroder Salvatore Campanella Philippe Fontaine Charles Kornreich |
| author_sort | Aurore Monnart |
| collection | DOAJ |
| description | Background: This pilot study explores a therapeutic setting combining transcranial direct current stimulation (tDCS) and mindfulness-based cognitive therapy (MBCT) for patients with drug-resistant depression. tDCS has shown efficacy for depression treatment and improvement could be maintained with the combination with mindfulness, which has shown depression relapse-prevention properties.Methods: Thirty-one treatment-resistant depressed patients have been assigned to our experimental treatment condition [tDCS combined with MBCT (n = 15)] or to a control condition [tDCS combined with relaxation (n = 16)]. Patients have completed both an intensive treatment block (eight consecutive days) and a single remind session 2 weeks after the intensive treatment. Clinical (depression, anxiety, and rumination) and cognitive (general cognitive functioning, mental flexibility, and working memory) symptoms of depression have been assessed through different questionnaires at baseline (t0), after the first block of treatment (t1), and after the remind session (t2).Results: Results seem to indicate a positive impact of both treatment conditions on clinical and cognitive symptoms of depression at t1. However, the treatment condition combining tDCS with mindfulness has been found to better maintain clinical improvements at t2 regarding some clinical [Montgomery–Åsberg Depression Rating Scale (MADRS) and Sadness and Anger Ruminative Inventory (SARI)] and cognitive variables (Digit Span-F and Digit Span-B).Conclusion: Based on the current observations, a multi-disciplinary treatment approach combining tDCS and MBCT might be effective in resistant depressed patients in the long run, even though further clinical research is necessary. |
| first_indexed | 2024-04-14T08:03:09Z |
| format | Article |
| id | doaj.art-4227ee0eb8f04ceba1374fe7ad200087 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-14T08:03:09Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-4227ee0eb8f04ceba1374fe7ad2000872022-12-22T02:04:50ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-10-011010.3389/fpsyt.2019.00730435182Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation ProgramAurore Monnart0Marie-Anne Vanderhasselt1Marie-Anne Vanderhasselt2Elisa Schroder3Salvatore Campanella4Philippe Fontaine5Charles Kornreich6Laboratory of Psychological Medicine and Addictology, CHU Brugmann - ULB Neuroscience Institue (UNI), University of Brussels (ULB), Brussels, BelgiumDepartment of Head and Skin, Ghent Experimental Psychiatry Lab, Ghent University (UGent), Ghent, BelgiumDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, BelgiumLaboratory of Psychological Medicine and Addictology, CHU Brugmann - ULB Neuroscience Institue (UNI), University of Brussels (ULB), Brussels, BelgiumLaboratory of Psychological Medicine and Addictology, CHU Brugmann - ULB Neuroscience Institue (UNI), University of Brussels (ULB), Brussels, BelgiumDepartment of Psychiatry, CHU de Charleroi, Charleroi, BelgiumLaboratory of Psychological Medicine and Addictology, CHU Brugmann - ULB Neuroscience Institue (UNI), University of Brussels (ULB), Brussels, BelgiumBackground: This pilot study explores a therapeutic setting combining transcranial direct current stimulation (tDCS) and mindfulness-based cognitive therapy (MBCT) for patients with drug-resistant depression. tDCS has shown efficacy for depression treatment and improvement could be maintained with the combination with mindfulness, which has shown depression relapse-prevention properties.Methods: Thirty-one treatment-resistant depressed patients have been assigned to our experimental treatment condition [tDCS combined with MBCT (n = 15)] or to a control condition [tDCS combined with relaxation (n = 16)]. Patients have completed both an intensive treatment block (eight consecutive days) and a single remind session 2 weeks after the intensive treatment. Clinical (depression, anxiety, and rumination) and cognitive (general cognitive functioning, mental flexibility, and working memory) symptoms of depression have been assessed through different questionnaires at baseline (t0), after the first block of treatment (t1), and after the remind session (t2).Results: Results seem to indicate a positive impact of both treatment conditions on clinical and cognitive symptoms of depression at t1. However, the treatment condition combining tDCS with mindfulness has been found to better maintain clinical improvements at t2 regarding some clinical [Montgomery–Åsberg Depression Rating Scale (MADRS) and Sadness and Anger Ruminative Inventory (SARI)] and cognitive variables (Digit Span-F and Digit Span-B).Conclusion: Based on the current observations, a multi-disciplinary treatment approach combining tDCS and MBCT might be effective in resistant depressed patients in the long run, even though further clinical research is necessary.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00730/fullmajor depressive disordertranscranial direct current stimulation (tDCS)mindfulness-based cognitive therapyruminationcognitive control |
| spellingShingle | Aurore Monnart Marie-Anne Vanderhasselt Marie-Anne Vanderhasselt Elisa Schroder Salvatore Campanella Philippe Fontaine Charles Kornreich Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program Frontiers in Psychiatry major depressive disorder transcranial direct current stimulation (tDCS) mindfulness-based cognitive therapy rumination cognitive control |
| title | Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program |
| title_full | Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program |
| title_fullStr | Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program |
| title_full_unstemmed | Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program |
| title_short | Treatment of Resistant Depression: A Pilot Study Assessing the Efficacy of a tDCS-Mindfulness Program Compared With a tDCS-Relaxation Program |
| title_sort | treatment of resistant depression a pilot study assessing the efficacy of a tdcs mindfulness program compared with a tdcs relaxation program |
| topic | major depressive disorder transcranial direct current stimulation (tDCS) mindfulness-based cognitive therapy rumination cognitive control |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00730/full |
| work_keys_str_mv | AT auroremonnart treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram AT marieannevanderhasselt treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram AT marieannevanderhasselt treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram AT elisaschroder treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram AT salvatorecampanella treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram AT philippefontaine treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram AT charleskornreich treatmentofresistantdepressionapilotstudyassessingtheefficacyofatdcsmindfulnessprogramcomparedwithatdcsrelaxationprogram |