Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells

Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells

Radiotherapy is an important modality for the local control of human cancers, but the radioresistance induced by aberrant apoptotic signaling is a hallmark of cancers. Restoring the aberrant apoptotic pathways is an emerging strategy for cancer radiotherapy. In this study, we determined that targeti...

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Bibliographic Details
Main Authors: Yang Gao, Pengbo Wen, Bin Chen, Guanshuo Hu, Lijun Wu, An Xu, Guoping Zhao
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
CDC20
radiotherapy
Mcl-1
p-Chk1
mitochondrial-dependent apoptotic pathway
Online Access:https://www.mdpi.com/1422-0067/21/18/6692

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