Effects of Thinner Inhalation on the Rat Nasal Mucosa
People are exposed to volatile substances by inhalation, skin contact or oral intake, because these are widely used in industry. In recent years these substances are abused for their euphoric effects, especially thinner. Among these substances, thinner is the choice of the young people with low soci...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2004-09-01
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| Series: | Turkish Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/effects-of-thinner-nhalation-on-the-rat-nasal-muco/43705
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| _version_ | 1797911372759040000 |
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| author | Sema Zer Toros Tanju Gökçeer Çınar Akkaynak Osman Karaaslan Saime Sezgin Çiğdem Çelikel Burak Toros |
| author_facet | Sema Zer Toros Tanju Gökçeer Çınar Akkaynak Osman Karaaslan Saime Sezgin Çiğdem Çelikel Burak Toros |
| author_sort | Sema Zer Toros |
| collection | DOAJ |
| description | People are exposed to volatile substances by inhalation, skin contact or oral intake, because these are widely used in industry. In recent years these substances are abused for their euphoric effects, especially thinner. Among these substances, thinner is the choice of the young people with low socioeconomic level and familial problems due to the expense, hardness to find and illegality of other drugs. In addition, many more are unwillingly exposed to these substances at work. So it’s becoming more important to find out the effects of thinner inhalation on nasal mucosa. This experimental study was performed to evaluate the effects of thinner on the nasal mucosa. Four groups were dispersed due to inhalation periods. Exposure periods of the first, second, third and fourth groups were 1 week, 3 weeks, 4 weeks and 5 weeks respectively. Thinner inhaled animals lost weight within weeks. Loss of weight in the third group was found to be statistically significant compared to other groups and controls (p<0.05). Central nervous system toxicity was observed in the thinner inhaled groups. Inflammatory response which was most prominent in the first group decreased within weeks. But in comparison with other groups, the difference was statistically not significant (p>0.05). Squamous metaplasia, epithelial stratification and budding were formed by the first week; but no statistically significant increase was detected till the end of the 5th week (p>0.05). Epithelial villous hypertrophy appeared in the second group and became significantly prominent during following weeks in other groups as well (p<0.01). In conclusion, villous formations, budding, stratifications which are different forms of epithelial hyperplasia; and squamous metaplasia were observed in the nasal mucosa which exposed to thinner. So it was shown that thinner is harmful for the nasal mucosa as well as for the other organs of the respiratory system. |
| first_indexed | 2024-04-10T11:40:39Z |
| format | Article |
| id | doaj.art-422ad561725b4eb6ac13f6fa6f4f8b92 |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T11:40:39Z |
| publishDate | 2004-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-422ad561725b4eb6ac13f6fa6f4f8b922023-02-15T16:17:34ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742004-09-0142314014813049054Effects of Thinner Inhalation on the Rat Nasal MucosaSema Zer Toros0Tanju Gökçeer1Çınar Akkaynak2Osman Karaaslan3Saime Sezgin4Çiğdem Çelikel5Burak Toros6 Haydarpaşa Numune Hospital, Department of Otorhinolaryngology & Head and Neck Surgery, Istanbul Haydarpaşa Numune Hospital, Department of Otorhinolaryngology & Head and Neck Surgery, Istanbul Haydarpaşa Numune Hospital, Department of Otorhinolaryngology & Head and Neck Surgery, Istanbul Haydarpaşa Numune Hospital, Department of Otorhinolaryngology & Head and Neck Surgery, Istanbul Marmara University, Faculty of Medicine, Department of Pathology, Istanbul Marmara University, Faculty of Medicine, Department of Pathology, Istanbul Haydarpafla Numune Hospital, Department of Gastroenterology, Istanbul People are exposed to volatile substances by inhalation, skin contact or oral intake, because these are widely used in industry. In recent years these substances are abused for their euphoric effects, especially thinner. Among these substances, thinner is the choice of the young people with low socioeconomic level and familial problems due to the expense, hardness to find and illegality of other drugs. In addition, many more are unwillingly exposed to these substances at work. So it’s becoming more important to find out the effects of thinner inhalation on nasal mucosa. This experimental study was performed to evaluate the effects of thinner on the nasal mucosa. Four groups were dispersed due to inhalation periods. Exposure periods of the first, second, third and fourth groups were 1 week, 3 weeks, 4 weeks and 5 weeks respectively. Thinner inhaled animals lost weight within weeks. Loss of weight in the third group was found to be statistically significant compared to other groups and controls (p<0.05). Central nervous system toxicity was observed in the thinner inhaled groups. Inflammatory response which was most prominent in the first group decreased within weeks. But in comparison with other groups, the difference was statistically not significant (p>0.05). Squamous metaplasia, epithelial stratification and budding were formed by the first week; but no statistically significant increase was detected till the end of the 5th week (p>0.05). Epithelial villous hypertrophy appeared in the second group and became significantly prominent during following weeks in other groups as well (p<0.01). In conclusion, villous formations, budding, stratifications which are different forms of epithelial hyperplasia; and squamous metaplasia were observed in the nasal mucosa which exposed to thinner. So it was shown that thinner is harmful for the nasal mucosa as well as for the other organs of the respiratory system. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/effects-of-thinner-nhalation-on-the-rat-nasal-muco/43705 thinnernasal mucosatoxicity. |
| spellingShingle | Sema Zer Toros Tanju Gökçeer Çınar Akkaynak Osman Karaaslan Saime Sezgin Çiğdem Çelikel Burak Toros Effects of Thinner Inhalation on the Rat Nasal Mucosa Turkish Archives of Otorhinolaryngology thinner nasal mucosa toxicity. |
| title | Effects of Thinner Inhalation on the Rat Nasal Mucosa |
| title_full | Effects of Thinner Inhalation on the Rat Nasal Mucosa |
| title_fullStr | Effects of Thinner Inhalation on the Rat Nasal Mucosa |
| title_full_unstemmed | Effects of Thinner Inhalation on the Rat Nasal Mucosa |
| title_short | Effects of Thinner Inhalation on the Rat Nasal Mucosa |
| title_sort | effects of thinner inhalation on the rat nasal mucosa |
| topic | thinner nasal mucosa toxicity. |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/effects-of-thinner-nhalation-on-the-rat-nasal-muco/43705
|
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