Preparation of hybrid biomaterials for bone tissue engineering
Tissue engineering has evolved from the use of biomaterials for bone substitution that fulfill the clinical demands of biocompatibility, biodegradability, non-immunogeneity, structural strength and porosity. Porous scaffolds have been developed in many forms and materials, but few reached the need o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2007-03-01
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| Series: | Materials Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392007000100006 |
| _version_ | 1811235078754271232 |
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| author | Vilma Conceição Costa Hermes Souza Costa Wander Luiz Vasconcelos Marivalda de Magalhães Pereira Rodrigo Lambert Oréfice Herman Sander Mansur |
| author_facet | Vilma Conceição Costa Hermes Souza Costa Wander Luiz Vasconcelos Marivalda de Magalhães Pereira Rodrigo Lambert Oréfice Herman Sander Mansur |
| author_sort | Vilma Conceição Costa |
| collection | DOAJ |
| description | Tissue engineering has evolved from the use of biomaterials for bone substitution that fulfill the clinical demands of biocompatibility, biodegradability, non-immunogeneity, structural strength and porosity. Porous scaffolds have been developed in many forms and materials, but few reached the need of adequate physical, biological and mechanical properties. In the present paper we report the preparation of hybrid porous polyvinyl alcohol (PVA)/bioactive glass through the sol-gel route, using partially and fully hydrolyzed polyvinyl alcohol, and perform structural characterization. Hybrids containing PVA and bioactive glass with composition 58SiO2-33CaO-9P2O5 were synthesized by foaming a mixture of polymer solution and bioactive glass sol-gel precursor solution. Sol-gel solution was prepared from mixing tetraethoxysilane (TEOS), triethylphosphate (TEP), and calcium chloride as chemical precursors. The hybrid composites obtained after aging and drying at low temperature were chemically and morphologically characterized through infrared spectroscopy and scanning electron microscopy. The degree of hydrolysis of PVA, concentration of PVA solution and different PVA-bioglass composition ratios affect the synthesis procedure. Synthesis parameters must be very well combined in order to allow foaming and gelation. The hybrid scaffolds obtained exhibited macroporous structure with pore size varying from 50 to 600 µm. |
| first_indexed | 2024-04-12T11:46:01Z |
| format | Article |
| id | doaj.art-422b767397e44005b6f92ceda4e09e33 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-04-12T11:46:01Z |
| publishDate | 2007-03-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-422b767397e44005b6f92ceda4e09e332022-12-22T03:34:22ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392007-03-01101212610.1590/S1516-14392007000100006Preparation of hybrid biomaterials for bone tissue engineeringVilma Conceição CostaHermes Souza CostaWander Luiz VasconcelosMarivalda de Magalhães PereiraRodrigo Lambert OréficeHerman Sander MansurTissue engineering has evolved from the use of biomaterials for bone substitution that fulfill the clinical demands of biocompatibility, biodegradability, non-immunogeneity, structural strength and porosity. Porous scaffolds have been developed in many forms and materials, but few reached the need of adequate physical, biological and mechanical properties. In the present paper we report the preparation of hybrid porous polyvinyl alcohol (PVA)/bioactive glass through the sol-gel route, using partially and fully hydrolyzed polyvinyl alcohol, and perform structural characterization. Hybrids containing PVA and bioactive glass with composition 58SiO2-33CaO-9P2O5 were synthesized by foaming a mixture of polymer solution and bioactive glass sol-gel precursor solution. Sol-gel solution was prepared from mixing tetraethoxysilane (TEOS), triethylphosphate (TEP), and calcium chloride as chemical precursors. The hybrid composites obtained after aging and drying at low temperature were chemically and morphologically characterized through infrared spectroscopy and scanning electron microscopy. The degree of hydrolysis of PVA, concentration of PVA solution and different PVA-bioglass composition ratios affect the synthesis procedure. Synthesis parameters must be very well combined in order to allow foaming and gelation. The hybrid scaffolds obtained exhibited macroporous structure with pore size varying from 50 to 600 µm.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392007000100006biomaterialbioceramicspolymertissue engineeringhybridssol-gelbioglass |
| spellingShingle | Vilma Conceição Costa Hermes Souza Costa Wander Luiz Vasconcelos Marivalda de Magalhães Pereira Rodrigo Lambert Oréfice Herman Sander Mansur Preparation of hybrid biomaterials for bone tissue engineering Materials Research biomaterial bioceramics polymer tissue engineering hybrids sol-gel bioglass |
| title | Preparation of hybrid biomaterials for bone tissue engineering |
| title_full | Preparation of hybrid biomaterials for bone tissue engineering |
| title_fullStr | Preparation of hybrid biomaterials for bone tissue engineering |
| title_full_unstemmed | Preparation of hybrid biomaterials for bone tissue engineering |
| title_short | Preparation of hybrid biomaterials for bone tissue engineering |
| title_sort | preparation of hybrid biomaterials for bone tissue engineering |
| topic | biomaterial bioceramics polymer tissue engineering hybrids sol-gel bioglass |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392007000100006 |
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