Proteomics of protein trafficking by in vivo tissue-specific labeling
The network of proteins secreted for interorgan communication is poorly understood. Here, the authors develop a method, based on protein labeling, to study cell-specific secretomes and interorgan protein trafficking, and demonstrate their approach in Drosophila and mouse models.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22599-x |
| _version_ | 1818842899571277824 |
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| author | Ilia A. Droujinine Amanda S. Meyer Dan Wang Namrata D. Udeshi Yanhui Hu David Rocco Jill A. McMahon Rui Yang JinJin Guo Luye Mu Dominique K. Carey Tanya Svinkina Rebecca Zeng Tess Branon Areya Tabatabai Justin A. Bosch John M. Asara Alice Y. Ting Steven A. Carr Andrew P. McMahon Norbert Perrimon |
| author_facet | Ilia A. Droujinine Amanda S. Meyer Dan Wang Namrata D. Udeshi Yanhui Hu David Rocco Jill A. McMahon Rui Yang JinJin Guo Luye Mu Dominique K. Carey Tanya Svinkina Rebecca Zeng Tess Branon Areya Tabatabai Justin A. Bosch John M. Asara Alice Y. Ting Steven A. Carr Andrew P. McMahon Norbert Perrimon |
| author_sort | Ilia A. Droujinine |
| collection | DOAJ |
| description | The network of proteins secreted for interorgan communication is poorly understood. Here, the authors develop a method, based on protein labeling, to study cell-specific secretomes and interorgan protein trafficking, and demonstrate their approach in Drosophila and mouse models. |
| first_indexed | 2024-12-19T04:49:18Z |
| format | Article |
| id | doaj.art-422c9afa42b14702bb8a2d8be8a9fe8e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:49:18Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-422c9afa42b14702bb8a2d8be8a9fe8e2022-12-21T20:35:24ZengNature PortfolioNature Communications2041-17232021-04-0112112210.1038/s41467-021-22599-xProteomics of protein trafficking by in vivo tissue-specific labelingIlia A. Droujinine0Amanda S. Meyer1Dan Wang2Namrata D. Udeshi3Yanhui Hu4David Rocco5Jill A. McMahon6Rui Yang7JinJin Guo8Luye Mu9Dominique K. Carey10Tanya Svinkina11Rebecca Zeng12Tess Branon13Areya Tabatabai14Justin A. Bosch15John M. Asara16Alice Y. Ting17Steven A. Carr18Andrew P. McMahon19Norbert Perrimon20Department of Genetics, Blavatnik Institute, Harvard Medical SchoolDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern CaliforniaDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolBroad Institute of Harvard and MITDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern CaliforniaDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern CaliforniaDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern CaliforniaDepartment of Electrical Engineering, Yale UniversityBroad Institute of Harvard and MITBroad Institute of Harvard and MITDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolChan Zuckerberg BiohubDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolDepartment of Medicine, Harvard Medical SchoolChan Zuckerberg BiohubBroad Institute of Harvard and MITDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern CaliforniaDepartment of Genetics, Blavatnik Institute, Harvard Medical SchoolThe network of proteins secreted for interorgan communication is poorly understood. Here, the authors develop a method, based on protein labeling, to study cell-specific secretomes and interorgan protein trafficking, and demonstrate their approach in Drosophila and mouse models.https://doi.org/10.1038/s41467-021-22599-x |
| spellingShingle | Ilia A. Droujinine Amanda S. Meyer Dan Wang Namrata D. Udeshi Yanhui Hu David Rocco Jill A. McMahon Rui Yang JinJin Guo Luye Mu Dominique K. Carey Tanya Svinkina Rebecca Zeng Tess Branon Areya Tabatabai Justin A. Bosch John M. Asara Alice Y. Ting Steven A. Carr Andrew P. McMahon Norbert Perrimon Proteomics of protein trafficking by in vivo tissue-specific labeling Nature Communications |
| title | Proteomics of protein trafficking by in vivo tissue-specific labeling |
| title_full | Proteomics of protein trafficking by in vivo tissue-specific labeling |
| title_fullStr | Proteomics of protein trafficking by in vivo tissue-specific labeling |
| title_full_unstemmed | Proteomics of protein trafficking by in vivo tissue-specific labeling |
| title_short | Proteomics of protein trafficking by in vivo tissue-specific labeling |
| title_sort | proteomics of protein trafficking by in vivo tissue specific labeling |
| url | https://doi.org/10.1038/s41467-021-22599-x |
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