Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial
Abstract Background Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients. However, conventional exercise is not always suitable for these patients due to physical weakness and therapeutic side effec...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4790-y |
| _version_ | 1818312330795024384 |
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| author | Kristin Schink Hans J. Herrmann Raphaela Schwappacher Julia Meyer Till Orlemann Elisabeth Waldmann Bernd Wullich Andreas Kahlmeyer Rainer Fietkau Dorota Lubgan Matthias W. Beckmann Carolin Hack Wolfgang Kemmler Jürgen Siebler Markus F. Neurath Yurdagül Zopf |
| author_facet | Kristin Schink Hans J. Herrmann Raphaela Schwappacher Julia Meyer Till Orlemann Elisabeth Waldmann Bernd Wullich Andreas Kahlmeyer Rainer Fietkau Dorota Lubgan Matthias W. Beckmann Carolin Hack Wolfgang Kemmler Jürgen Siebler Markus F. Neurath Yurdagül Zopf |
| author_sort | Kristin Schink |
| collection | DOAJ |
| description | Abstract Background Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients. However, conventional exercise is not always suitable for these patients due to physical weakness and therapeutic side effects. In this pilot study, we examined the effect of a combined approach of the novel training method whole-body electromyostimulation (WB-EMS) and individualized nutritional support on body composition with primary focus on skeletal muscle mass in advanced cancer patients under oncological treatment. Methods In a non-randomized controlled trial design patients (56.5% male; 59.9 ± 12.7 years) with advanced solid tumors (UICC III/IV, N = 131) undergoing anti-cancer therapy were allocated to a usual care control group (n = 35) receiving individualized nutritional support or to an intervention group (n = 96) that additionally performed a supervised physical exercise program in form of 20 min WB-EMS sessions (bipolar, 85 Hz) 2×/week for 12 weeks. The primary outcome of skeletal muscle mass and secondary outcomes of body composition, body weight and hand grip strength were measured at baseline, in weeks 4, 8 and 12 by bioelectrical impedance analysis and hand dynamometer. Effects of WB-EMS were estimated by linear mixed models. Secondary outcomes of physical function, hematological and blood chemistry parameters, quality of life and fatigue were assessed at baseline and week 12. Changes were analyzed by t-tests, Wilcoxon signed-rank or Mann-Whitney-U-tests. Results Twenty-four patients of the control and 58 of the WB-EMS group completed the 12-week trial. Patients of the WB-EMS group had a significantly higher skeletal muscle mass (0.53 kg [0.08, 0.98]; p = 0.022) and body weight (1.02 kg [0.05, 1.98]; p = 0.039) compared to controls at the end of intervention. WB-EMS also significantly improved physical function and performance status (p < 0.05). No significant differences of changes in quality of life, fatigue and blood parameters were detected between the study groups after 12 weeks. Conclusions Supervised WB-EMS training is a safe strength training method and combined with nutritional support it shows promising effects against muscle wasting and on physical function in advanced-stage cancer patients undergoing treatment. Trial registration ClinicalTrials.gov NCT02293239 (Date: November 18, 2014). |
| first_indexed | 2024-12-13T08:16:09Z |
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| id | doaj.art-422d9af3a49540d4b881fca3e48df53c |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T08:16:09Z |
| publishDate | 2018-09-01 |
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| series | BMC Cancer |
| spelling | doaj.art-422d9af3a49540d4b881fca3e48df53c2022-12-21T23:54:06ZengBMCBMC Cancer1471-24072018-09-0118111710.1186/s12885-018-4790-yEffects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trialKristin Schink0Hans J. Herrmann1Raphaela Schwappacher2Julia Meyer3Till Orlemann4Elisabeth Waldmann5Bernd Wullich6Andreas Kahlmeyer7Rainer Fietkau8Dorota Lubgan9Matthias W. Beckmann10Carolin Hack11Wolfgang Kemmler12Jürgen Siebler13Markus F. Neurath14Yurdagül Zopf15Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenInstitute of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)Department of Urology and Pediatric Urology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Urology and Pediatric Urology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Radiation Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Radiation Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Obstetrics and Gynaecology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Obstetrics and Gynaecology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenInstitute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenDepartment of Medicine 1 – Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital ErlangenAbstract Background Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients. However, conventional exercise is not always suitable for these patients due to physical weakness and therapeutic side effects. In this pilot study, we examined the effect of a combined approach of the novel training method whole-body electromyostimulation (WB-EMS) and individualized nutritional support on body composition with primary focus on skeletal muscle mass in advanced cancer patients under oncological treatment. Methods In a non-randomized controlled trial design patients (56.5% male; 59.9 ± 12.7 years) with advanced solid tumors (UICC III/IV, N = 131) undergoing anti-cancer therapy were allocated to a usual care control group (n = 35) receiving individualized nutritional support or to an intervention group (n = 96) that additionally performed a supervised physical exercise program in form of 20 min WB-EMS sessions (bipolar, 85 Hz) 2×/week for 12 weeks. The primary outcome of skeletal muscle mass and secondary outcomes of body composition, body weight and hand grip strength were measured at baseline, in weeks 4, 8 and 12 by bioelectrical impedance analysis and hand dynamometer. Effects of WB-EMS were estimated by linear mixed models. Secondary outcomes of physical function, hematological and blood chemistry parameters, quality of life and fatigue were assessed at baseline and week 12. Changes were analyzed by t-tests, Wilcoxon signed-rank or Mann-Whitney-U-tests. Results Twenty-four patients of the control and 58 of the WB-EMS group completed the 12-week trial. Patients of the WB-EMS group had a significantly higher skeletal muscle mass (0.53 kg [0.08, 0.98]; p = 0.022) and body weight (1.02 kg [0.05, 1.98]; p = 0.039) compared to controls at the end of intervention. WB-EMS also significantly improved physical function and performance status (p < 0.05). No significant differences of changes in quality of life, fatigue and blood parameters were detected between the study groups after 12 weeks. Conclusions Supervised WB-EMS training is a safe strength training method and combined with nutritional support it shows promising effects against muscle wasting and on physical function in advanced-stage cancer patients undergoing treatment. Trial registration ClinicalTrials.gov NCT02293239 (Date: November 18, 2014).http://link.springer.com/article/10.1186/s12885-018-4790-yAdvanced cancerCancer cachexiaNutritionPhysical exerciseSkeletal muscle massWB-EMS whole-body electromyostimulation |
| spellingShingle | Kristin Schink Hans J. Herrmann Raphaela Schwappacher Julia Meyer Till Orlemann Elisabeth Waldmann Bernd Wullich Andreas Kahlmeyer Rainer Fietkau Dorota Lubgan Matthias W. Beckmann Carolin Hack Wolfgang Kemmler Jürgen Siebler Markus F. Neurath Yurdagül Zopf Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial BMC Cancer Advanced cancer Cancer cachexia Nutrition Physical exercise Skeletal muscle mass WB-EMS whole-body electromyostimulation |
| title | Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial |
| title_full | Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial |
| title_fullStr | Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial |
| title_full_unstemmed | Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial |
| title_short | Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial |
| title_sort | effects of whole body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer a controlled pilot trial |
| topic | Advanced cancer Cancer cachexia Nutrition Physical exercise Skeletal muscle mass WB-EMS whole-body electromyostimulation |
| url | http://link.springer.com/article/10.1186/s12885-018-4790-y |
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