MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors

MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors

MICA and MICB are Class I MHC-related glycoproteins that are upregulated on the surface of cells in response to stress, for instance due to infection or malignant transformation. MICA/B are ligands for NKG2D, an activating receptor on NK cells, CD8+ T cells, and γδ T cells. Upon engagement of MICA/B...

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Bibliographic Details
Main Authors: Elisha R. Verhaar, Anouk Knoflook, Novalia Pishesha, Xin Liu, Willemijn J. C. van Keizerswaard, Kai W. Wucherpfennig, Hidde L. Ploegh
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
MICA
NKG2D
NKG2D ligands
cancer
nanobodies
VHHs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368586/full

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