Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV
Introduction: Infections caused by Chlamydia trachomatis (CT) and Human Papilloma Virus (HPV) are among the most prevalent sexually transmitted infections (STIs) worldwide. CT infection in women living with the human immunodeficiency virus (HIV) can facilitate HIV transmission by increasing HIV she...
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| Format: | Article |
| Language: | English |
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Zeppelini Editorial e Comunicacao
2021-12-01
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| Series: | DST |
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| Online Access: | https://bjstd.org/revista/article/view/730 |
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| author | Sara Pereira Leite Lima Caroline Alves de Oliveira Martins Yara Lúcia Mendes Furtado de Melo Svitrigaile Grinceviciene Susana Cristina Aidé Viviani Fialho Luisa Czeresnia Costa Bond Luis Guillermo Coca Velarde Isabel Cristina Chulvis Guimarães do Val |
| author_facet | Sara Pereira Leite Lima Caroline Alves de Oliveira Martins Yara Lúcia Mendes Furtado de Melo Svitrigaile Grinceviciene Susana Cristina Aidé Viviani Fialho Luisa Czeresnia Costa Bond Luis Guillermo Coca Velarde Isabel Cristina Chulvis Guimarães do Val |
| author_sort | Sara Pereira Leite Lima |
| collection | DOAJ |
| description |
Introduction: Infections caused by Chlamydia trachomatis (CT) and Human Papilloma Virus (HPV) are among the most prevalent sexually transmitted infections (STIs) worldwide. CT infection in women living with the human immunodeficiency virus (HIV) can facilitate HIV transmission by increasing HIV shedding in cervicovaginal secretions. The prevalence of Human papillomavirus (HPV) infection is higher in women living with HIV when compared to HIV-negative women, even when comparing those with the same sociodemographic characteristics. Generally, they have a high viral load and a higher persistence of viral infection, which increases the risk of developing premalignant and malignant lesions in the lower genital tract. Objective: To evaluate the frequency of CT and High-Risk HPV (HR-HPV) infection among women living with HIV and the association with sociodemographic, behavioral and clinical characteristics. Methods: Cross-sectional study carried out with a population of 66 non-pregnant women aged between 18 and 70 years living with HIV and/or acquired immunodeficiency syndrome (AIDS) at the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense (UFF), Niterói (RJ), Brazil, between the period of March 1, 2018 and October 31, 2018. A standardized questionnaire was applied including sociodemographic and behavioral characteristics, and clinical information (use of oral contraceptives, Antiretroviral Therapy (ART), cluster of differentiation 4 (CD4) cell count, and viral load). Endocervical samples were collected for CT (COBAS 4800® system, Roche) and HPV (COBAS® HPV test, Roche) detection. Fisher's Exact Test was used to assess the association between variables. Regression analyses were performed using the logistic model in order to identify the factors associated with the outcomes of interest. Results: A frequency of 1.5% for CT and 21.2% for HR-HPV was found. Age was the single factor that presented statistical significance associated with HR-HPV infection. Conclusion: Our study showed that some women living with HIV promote risky behavior which could facilitate the acquisition of other STIs, such as HPV and CT infection. Some of them, with detected viral load, were not using condoms even with HIV-negative partners. These results may suggest that in addition to treatment and follow-up of women living with HIV, STIs counseling and guidance may play an important role in the control of STIs in this population.
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| first_indexed | 2024-04-10T19:55:50Z |
| format | Article |
| id | doaj.art-42323ab4a47d417998f2c89ba0bf8e80 |
| institution | Directory Open Access Journal |
| issn | 2177-8264 |
| language | English |
| last_indexed | 2024-04-10T19:55:50Z |
| publishDate | 2021-12-01 |
| publisher | Zeppelini Editorial e Comunicacao |
| record_format | Article |
| series | DST |
| spelling | doaj.art-42323ab4a47d417998f2c89ba0bf8e802023-01-28T01:05:39ZengZeppelini Editorial e ComunicacaoDST2177-82642021-12-0133Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIVSara Pereira Leite Lima0Caroline Alves de Oliveira Martins1Yara Lúcia Mendes Furtado de Melo2Svitrigaile GrincevicieneSusana Cristina Aidé Viviani Fialho3Luisa Czeresnia Costa Bond4Luis Guillermo Coca Velarde5Isabel Cristina Chulvis Guimarães do Val6Universidade Federal Fluminense – Niterói (RJ), BrazilUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal Fluminense Universidade Federal Fluminense Introduction: Infections caused by Chlamydia trachomatis (CT) and Human Papilloma Virus (HPV) are among the most prevalent sexually transmitted infections (STIs) worldwide. CT infection in women living with the human immunodeficiency virus (HIV) can facilitate HIV transmission by increasing HIV shedding in cervicovaginal secretions. The prevalence of Human papillomavirus (HPV) infection is higher in women living with HIV when compared to HIV-negative women, even when comparing those with the same sociodemographic characteristics. Generally, they have a high viral load and a higher persistence of viral infection, which increases the risk of developing premalignant and malignant lesions in the lower genital tract. Objective: To evaluate the frequency of CT and High-Risk HPV (HR-HPV) infection among women living with HIV and the association with sociodemographic, behavioral and clinical characteristics. Methods: Cross-sectional study carried out with a population of 66 non-pregnant women aged between 18 and 70 years living with HIV and/or acquired immunodeficiency syndrome (AIDS) at the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense (UFF), Niterói (RJ), Brazil, between the period of March 1, 2018 and October 31, 2018. A standardized questionnaire was applied including sociodemographic and behavioral characteristics, and clinical information (use of oral contraceptives, Antiretroviral Therapy (ART), cluster of differentiation 4 (CD4) cell count, and viral load). Endocervical samples were collected for CT (COBAS 4800® system, Roche) and HPV (COBAS® HPV test, Roche) detection. Fisher's Exact Test was used to assess the association between variables. Regression analyses were performed using the logistic model in order to identify the factors associated with the outcomes of interest. Results: A frequency of 1.5% for CT and 21.2% for HR-HPV was found. Age was the single factor that presented statistical significance associated with HR-HPV infection. Conclusion: Our study showed that some women living with HIV promote risky behavior which could facilitate the acquisition of other STIs, such as HPV and CT infection. Some of them, with detected viral load, were not using condoms even with HIV-negative partners. These results may suggest that in addition to treatment and follow-up of women living with HIV, STIs counseling and guidance may play an important role in the control of STIs in this population. https://bjstd.org/revista/article/view/730Chlamydia trachomatissexually transmitted diseasesPapillomaviridaeHIVwomen |
| spellingShingle | Sara Pereira Leite Lima Caroline Alves de Oliveira Martins Yara Lúcia Mendes Furtado de Melo Svitrigaile Grinceviciene Susana Cristina Aidé Viviani Fialho Luisa Czeresnia Costa Bond Luis Guillermo Coca Velarde Isabel Cristina Chulvis Guimarães do Val Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV DST Chlamydia trachomatis sexually transmitted diseases Papillomaviridae HIV women |
| title | Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV |
| title_full | Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV |
| title_fullStr | Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV |
| title_full_unstemmed | Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV |
| title_short | Evaluation of chlamydia trachomatis and HR-HPV infection in women living with HIV |
| title_sort | evaluation of chlamydia trachomatis and hr hpv infection in women living with hiv |
| topic | Chlamydia trachomatis sexually transmitted diseases Papillomaviridae HIV women |
| url | https://bjstd.org/revista/article/view/730 |
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