Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer
Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558621000221 |
| _version_ | 1818441980998320128 |
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| author | Runping Fang Lihong Ye Hui Shi |
| author_facet | Runping Fang Lihong Ye Hui Shi |
| author_sort | Runping Fang |
| collection | DOAJ |
| description | Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for breast cancer treatment. Here we briefly outline the functions of m6A and its regulatory proteins, including m6A “writers,” “readers,” and “erasers” on RNA life fate, recapitulate the latest breakthroughs in understanding m6A modification and its regulatory proteins, and the underlying molecular mechanisms that contribute to the carcinogenesis and the progression of breast cancer, so as to provide potential epigenetic targets for diagnosis, treatment and prognosis in breast cancer. |
| first_indexed | 2024-12-14T18:36:53Z |
| format | Article |
| id | doaj.art-423278700a05478e9c4508b952d92bb0 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-12-14T18:36:53Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-423278700a05478e9c4508b952d92bb02022-12-21T22:51:35ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862021-06-01236551560Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancerRunping Fang0Lihong Ye1Hui Shi2State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, ChinaState Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, China; Corresponding author.Institute of Immunology and Molecular Medicine, Jining Medical University, Shandong, China; Corresponding author.Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for breast cancer treatment. Here we briefly outline the functions of m6A and its regulatory proteins, including m6A “writers,” “readers,” and “erasers” on RNA life fate, recapitulate the latest breakthroughs in understanding m6A modification and its regulatory proteins, and the underlying molecular mechanisms that contribute to the carcinogenesis and the progression of breast cancer, so as to provide potential epigenetic targets for diagnosis, treatment and prognosis in breast cancer.http://www.sciencedirect.com/science/article/pii/S1476558621000221m6A modificationEpigeneticsMethyltransferaseDemethylasem6A readerBreast cancer |
| spellingShingle | Runping Fang Lihong Ye Hui Shi Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer Neoplasia: An International Journal for Oncology Research m6A modification Epigenetics Methyltransferase Demethylase m6A reader Breast cancer |
| title | Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer |
| title_full | Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer |
| title_fullStr | Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer |
| title_full_unstemmed | Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer |
| title_short | Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer |
| title_sort | understanding the roles of n6 methyladenosine writers readers and erasers in breast cancer |
| topic | m6A modification Epigenetics Methyltransferase Demethylase m6A reader Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1476558621000221 |
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