Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis
Atherosclerosis is an inflammatory disease depending on the buildup, called plaque, of lipoproteins, cholesterol, extracellular matrix elements, and various types of immune and non-immune cells on the artery walls. Plaque development and growth lead to the narrowing of the blood vessel lumen, blocki...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14154 |
| _version_ | 1797465094885474304 |
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| author | Malgorzata Kloc Jacek Z. Kubiak Rafik M. Ghobrial |
| author_facet | Malgorzata Kloc Jacek Z. Kubiak Rafik M. Ghobrial |
| author_sort | Malgorzata Kloc |
| collection | DOAJ |
| description | Atherosclerosis is an inflammatory disease depending on the buildup, called plaque, of lipoproteins, cholesterol, extracellular matrix elements, and various types of immune and non-immune cells on the artery walls. Plaque development and growth lead to the narrowing of the blood vessel lumen, blocking blood flow, and eventually may lead to plaque burst and a blood clot. The prominent cellular components of atherosclerotic plaque are the foam cells, which, by trying to remove lipoprotein and cholesterol surplus, also participate in plaque development and rupture. Although the common knowledge is that the foam cells derive from macrophages, studies of the last decade clearly showed that macrophages are not the only cells able to form foam cells in atherosclerotic plaque. These findings give a new perspective on atherosclerotic plaque formation and composition and define new targets for anti-foam cell therapies for atherosclerosis prevention. This review gives a concise description of foam cells of different pedigrees and describes the main mechanisms participating in their formation and function. |
| first_indexed | 2024-03-09T18:16:32Z |
| format | Article |
| id | doaj.art-4232ef7cc57847c38f3dd7ffe67d3160 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:16:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4232ef7cc57847c38f3dd7ffe67d31602023-11-24T08:39:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221415410.3390/ijms232214154Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in AtherosclerosisMalgorzata Kloc0Jacek Z. Kubiak1Rafik M. Ghobrial2Transplant Immunology, The Houston Methodist Research Institute, Houston, TX 77030, USADynamics and Mechanics of Epithelia Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes, CNRS, UMR 6290, 35043 Rennes, FranceTransplant Immunology, The Houston Methodist Research Institute, Houston, TX 77030, USAAtherosclerosis is an inflammatory disease depending on the buildup, called plaque, of lipoproteins, cholesterol, extracellular matrix elements, and various types of immune and non-immune cells on the artery walls. Plaque development and growth lead to the narrowing of the blood vessel lumen, blocking blood flow, and eventually may lead to plaque burst and a blood clot. The prominent cellular components of atherosclerotic plaque are the foam cells, which, by trying to remove lipoprotein and cholesterol surplus, also participate in plaque development and rupture. Although the common knowledge is that the foam cells derive from macrophages, studies of the last decade clearly showed that macrophages are not the only cells able to form foam cells in atherosclerotic plaque. These findings give a new perspective on atherosclerotic plaque formation and composition and define new targets for anti-foam cell therapies for atherosclerosis prevention. This review gives a concise description of foam cells of different pedigrees and describes the main mechanisms participating in their formation and function.https://www.mdpi.com/1422-0067/23/22/14154foam cellsatherosclerosischolesterolmacrophagesdendritic cellssmooth muscle cells |
| spellingShingle | Malgorzata Kloc Jacek Z. Kubiak Rafik M. Ghobrial Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis International Journal of Molecular Sciences foam cells atherosclerosis cholesterol macrophages dendritic cells smooth muscle cells |
| title | Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis |
| title_full | Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis |
| title_fullStr | Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis |
| title_full_unstemmed | Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis |
| title_short | Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis |
| title_sort | macrophage dendritic smooth muscle endothelium and stem cells derived foam cells in atherosclerosis |
| topic | foam cells atherosclerosis cholesterol macrophages dendritic cells smooth muscle cells |
| url | https://www.mdpi.com/1422-0067/23/22/14154 |
| work_keys_str_mv | AT malgorzatakloc macrophagedendriticsmoothmuscleendotheliumandstemcellsderivedfoamcellsinatherosclerosis AT jacekzkubiak macrophagedendriticsmoothmuscleendotheliumandstemcellsderivedfoamcellsinatherosclerosis AT rafikmghobrial macrophagedendriticsmoothmuscleendotheliumandstemcellsderivedfoamcellsinatherosclerosis |