Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom
Purpose: Enterococci are a common cause of urinary tract infection and vancomycin-resistant strains are more difficult to treat. The purpose of this surveillance program was to assess the prevalence of and determine the risk factors for vancomycin resistance in adults among urinary isolates of Ent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2016-03-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-129.pdf |
| _version_ | 1818411579512717312 |
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| author | Liam Toner Nathan Papa Sani H. Aliyu Harveer Dev Nathan Lawrentschuk Samih Al-Hayek |
| author_facet | Liam Toner Nathan Papa Sani H. Aliyu Harveer Dev Nathan Lawrentschuk Samih Al-Hayek |
| author_sort | Liam Toner |
| collection | DOAJ |
| description | Purpose: Enterococci are a common cause of urinary tract infection and vancomycin-resistant strains are more difficult to treat.
The purpose of this surveillance program was to assess the prevalence of and determine the risk factors for vancomycin resistance
in adults among urinary isolates of Enterococcus sp. and to detail the antibiotic susceptibility profile, which can be used to guide
empirical treatment.
Materials and Methods: From 2005 to 2014 we retrospectively reviewed 5,528 positive Enterococcus sp. urine cultures recorded
in a computerized laboratory results database at a tertiary teaching hospital in Cambridge, United Kingdom.
Results: Of these cultures, 542 (9.8%) were vancomycin resistant. No longitudinal trend was observed in the proportion of vancomycin-
resistant strains over the course of the study. We observed emerging resistance to nitrofurantoin with rates climbing from
near zero to 40%. Ampicillin resistance fluctuated between 50% and 90%. Low resistance was observed for linezolid and quinupristin/
dalfopristin. Female sex and inpatient status were identified as risk factors for vancomycin resistance.
Conclusions: The incidence of vancomycin resistance among urinary isolates was stable over the last decade. Although resistance
to nitrofurantoin has increased, it still serves as an appropriate first choice in uncomplicated urinary tract infection caused by vancomycin-
resistant Enterococcus sp. |
| first_indexed | 2024-12-14T10:33:40Z |
| format | Article |
| id | doaj.art-4234aedbcd744672a0e2391490f19062 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-14T10:33:40Z |
| publishDate | 2016-03-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-4234aedbcd744672a0e2391490f190622022-12-21T23:06:03ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2016-03-0157212913410.4111/icu.2016.57.2.129Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United KingdomLiam Toner0Nathan Papa1Sani H. Aliyu2Harveer Dev3Nathan Lawrentschuk4Samih Al-Hayek5University of MelbourneUniversity of MelbourneCambridge UniversityCambridge UniversityUniversity of MelbourneCambridge UniversityPurpose: Enterococci are a common cause of urinary tract infection and vancomycin-resistant strains are more difficult to treat. The purpose of this surveillance program was to assess the prevalence of and determine the risk factors for vancomycin resistance in adults among urinary isolates of Enterococcus sp. and to detail the antibiotic susceptibility profile, which can be used to guide empirical treatment. Materials and Methods: From 2005 to 2014 we retrospectively reviewed 5,528 positive Enterococcus sp. urine cultures recorded in a computerized laboratory results database at a tertiary teaching hospital in Cambridge, United Kingdom. Results: Of these cultures, 542 (9.8%) were vancomycin resistant. No longitudinal trend was observed in the proportion of vancomycin- resistant strains over the course of the study. We observed emerging resistance to nitrofurantoin with rates climbing from near zero to 40%. Ampicillin resistance fluctuated between 50% and 90%. Low resistance was observed for linezolid and quinupristin/ dalfopristin. Female sex and inpatient status were identified as risk factors for vancomycin resistance. Conclusions: The incidence of vancomycin resistance among urinary isolates was stable over the last decade. Although resistance to nitrofurantoin has increased, it still serves as an appropriate first choice in uncomplicated urinary tract infection caused by vancomycin- resistant Enterococcus sp.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-129.pdfAntibiotic prophylaxis; Enterococcus; Microbial drug resistance; Urinary tract infection; Vancomycin-resistant enterococci |
| spellingShingle | Liam Toner Nathan Papa Sani H. Aliyu Harveer Dev Nathan Lawrentschuk Samih Al-Hayek Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom Investigative and Clinical Urology Antibiotic prophylaxis; Enterococcus; Microbial drug resistance; Urinary tract infection; Vancomycin-resistant enterococci |
| title | Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom |
| title_full | Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom |
| title_fullStr | Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom |
| title_full_unstemmed | Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom |
| title_short | Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom |
| title_sort | vancomycin resistant enterococci in urine cultures antibiotic susceptibility trends over a decade at a tertiary hospital in the united kingdom |
| topic | Antibiotic prophylaxis; Enterococcus; Microbial drug resistance; Urinary tract infection; Vancomycin-resistant enterococci |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-129.pdf |
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