Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study
Background and purposeMaternal circadian rhythms are important for maintaining maternal and fetal homeostasis. The maternal circadian system coordinates the internal clock of the fetus with environmental lighting conditions via the melatonin signal. The intensity and wavelength of daylight influence...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1043366/full |
| _version_ | 1828091707874344960 |
|---|---|
| author | Soyhan Bagci Astrid Wieduwilt Ebru Aileen Alsat Jana Blickwedel Brigitte Strizek Christian Di Battista Agnes Lachner Herbert Plischke Tamene Melaku Andreas Müller |
| author_facet | Soyhan Bagci Astrid Wieduwilt Ebru Aileen Alsat Jana Blickwedel Brigitte Strizek Christian Di Battista Agnes Lachner Herbert Plischke Tamene Melaku Andreas Müller |
| author_sort | Soyhan Bagci |
| collection | DOAJ |
| description | Background and purposeMaternal circadian rhythms are important for maintaining maternal and fetal homeostasis. The maternal circadian system coordinates the internal clock of the fetus with environmental lighting conditions via the melatonin signal. The intensity and wavelength of daylight influence nocturnal melatonin production. This study aims to evaluate the effect of environmental lighting conditions on melatonin production in pregnant women with reduced mobility during hospitalization.MethodsWe installed a human-centric lighting system with biodynamic effects (BDL, biodynamic lighting) in the patient rooms. The pregnant women in the patient rooms with standard indoor conditions served as a control group. The illuminance (lux) and dose of effective circadian irradiation (Hec) were recorded every 10 seconds by light dosimeters (Lucerne University, Switzerland) attached to the patients` clothing.ResultsWe analyzed the illuminance status of 47 pregnant women with a median (IQR) gestational age of 29.9 (25.4-32.3) weeks of gestation. The median illuminance in the control group was significantly lower (p<0.05) than in the BDL group in the morning and afternoon from day 1 to 5. BDL patients had a significantly higher effective circadian irradiation in the morning. The effective circadian irradiation showed a significant daily rhythm only in the BDL group. The BDL group had a significantly higher melatonin production on day 3 (p=0.006) and day 5 (p=0.012) than the control group median (IQR) nocturnal 6-Sulfatoxymelatonin excretion 15840 (10140-22160) ng/12h vs. 6141 (2080-11328) ng/12h on day 3 and 18780 (11320-23562) ng/12h vs. 6380 (3500-17600) ng/12h on day 5).ConclusionWe have demonstrated that dramatically altered lighting conditions of hospitalized pregnant women may be optimized by installing biodynamic lighting systems in the patient rooms resulting in the maintenance of nocturnal melatonin production in pregnant women. |
| first_indexed | 2024-04-11T06:17:15Z |
| format | Article |
| id | doaj.art-423540a0ec2c49a8be67a00df672829a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T06:17:15Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-423540a0ec2c49a8be67a00df672829a2022-12-22T04:41:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10433661043366Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot studySoyhan Bagci0Astrid Wieduwilt1Ebru Aileen Alsat2Jana Blickwedel3Brigitte Strizek4Christian Di Battista5Agnes Lachner6Herbert Plischke7Tamene Melaku8Andreas Müller9Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, GermanyDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, GermanyDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, GermanyDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, GermanyDepartment of Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, GermanyEngineering and Architecture, University of Lucerne, Lucerne, SwitzerlandApplied Sciences, Munich University, Munich, GermanyApplied Sciences, Munich University, Munich, GermanyDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, GermanyDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, GermanyBackground and purposeMaternal circadian rhythms are important for maintaining maternal and fetal homeostasis. The maternal circadian system coordinates the internal clock of the fetus with environmental lighting conditions via the melatonin signal. The intensity and wavelength of daylight influence nocturnal melatonin production. This study aims to evaluate the effect of environmental lighting conditions on melatonin production in pregnant women with reduced mobility during hospitalization.MethodsWe installed a human-centric lighting system with biodynamic effects (BDL, biodynamic lighting) in the patient rooms. The pregnant women in the patient rooms with standard indoor conditions served as a control group. The illuminance (lux) and dose of effective circadian irradiation (Hec) were recorded every 10 seconds by light dosimeters (Lucerne University, Switzerland) attached to the patients` clothing.ResultsWe analyzed the illuminance status of 47 pregnant women with a median (IQR) gestational age of 29.9 (25.4-32.3) weeks of gestation. The median illuminance in the control group was significantly lower (p<0.05) than in the BDL group in the morning and afternoon from day 1 to 5. BDL patients had a significantly higher effective circadian irradiation in the morning. The effective circadian irradiation showed a significant daily rhythm only in the BDL group. The BDL group had a significantly higher melatonin production on day 3 (p=0.006) and day 5 (p=0.012) than the control group median (IQR) nocturnal 6-Sulfatoxymelatonin excretion 15840 (10140-22160) ng/12h vs. 6141 (2080-11328) ng/12h on day 3 and 18780 (11320-23562) ng/12h vs. 6380 (3500-17600) ng/12h on day 5).ConclusionWe have demonstrated that dramatically altered lighting conditions of hospitalized pregnant women may be optimized by installing biodynamic lighting systems in the patient rooms resulting in the maintenance of nocturnal melatonin production in pregnant women.https://www.frontiersin.org/articles/10.3389/fendo.2022.1043366/fullpregnant womencircadian rhythmmelatoninhuman-centric lightingbiodynamic lighting |
| spellingShingle | Soyhan Bagci Astrid Wieduwilt Ebru Aileen Alsat Jana Blickwedel Brigitte Strizek Christian Di Battista Agnes Lachner Herbert Plischke Tamene Melaku Andreas Müller Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study Frontiers in Endocrinology pregnant women circadian rhythm melatonin human-centric lighting biodynamic lighting |
| title | Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study |
| title_full | Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study |
| title_fullStr | Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study |
| title_full_unstemmed | Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study |
| title_short | Biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization: A randomized prospective pilot study |
| title_sort | biodynamic lighting conditions preserve nocturnal melatonin production in pregnant women during hospitalization a randomized prospective pilot study |
| topic | pregnant women circadian rhythm melatonin human-centric lighting biodynamic lighting |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1043366/full |
| work_keys_str_mv | AT soyhanbagci biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT astridwieduwilt biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT ebruaileenalsat biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT janablickwedel biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT brigittestrizek biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT christiandibattista biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT agneslachner biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT herbertplischke biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT tamenemelaku biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy AT andreasmuller biodynamiclightingconditionspreservenocturnalmelatoninproductioninpregnantwomenduringhospitalizationarandomizedprospectivepilotstudy |