Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe
<p>Abstract</p> <p>Background</p> <p>The objective of these two GCP multicentre European clinical field studies was to evaluate the long-term efficacy and safety of a new imidacloprid/flumethrin collar (Seresto<sup>®</sup>, Bayer AnimalHealth, Investigationa...
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| Format: | Article |
| Language: | English |
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BMC
2012-03-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://www.parasitesandvectors.com/content/5/1/66 |
| _version_ | 1818857260506415104 |
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| author | Stanneck Dorothee Rass Julia Radeloff Isabel Kruedewagen Eva Le Sueur Christophe Hellmann Klaus Krieger Klemens |
| author_facet | Stanneck Dorothee Rass Julia Radeloff Isabel Kruedewagen Eva Le Sueur Christophe Hellmann Klaus Krieger Klemens |
| author_sort | Stanneck Dorothee |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The objective of these two GCP multicentre European clinical field studies was to evaluate the long-term efficacy and safety of a new imidacloprid/flumethrin collar (Seresto<sup>®</sup>, Bayer AnimalHealth, Investigational Veterinary Product(IVP)) in dogs and cats naturally infested with fleas and/or ticks in comparison to a dimpylat collar ("Ungezieferband fuer Hunde/fuer Katzen", Beaphar, Control Product (CP)).</p> <p>Methods</p> <p>232 (IVP) and 81 (CP) cats and 271(IVP) and 129 (CP) dogs were treated with either product according to label claims and formed the safety population. Flea and tick counts were conducted in monthly intervals for up to 8 months in the efficacy subpopulation consisting of 118 (IVP) + 47 (CP) cats and 197 (IVP) + 94 (CP) dogs. Efficacy was calculated as reduction of infestation rate within the same treatment group and statistically compared between the two treatment groups.</p> <p>Results</p> <p>Preventive efficacy against fleas in cats/dogs varied in the IVP group between 97.4%/94.1% and 100%/100% (overall mean: 98.3%/96.7%) throughout the 8 month period and in the CP group between 57.1%/28.2% and 96.1%/67.8% (overall mean: 79.3%/57.9%). Preventive efficacy against ticks in cats/dogs varied in the IVP group between 94.0%/91.2% and 100%/100% (overall mean: 98.4%/94.7%) throughout the 8 month period and in the CP group between 90.7%/79.9% and 100%/88.0% (overall mean: 96.9%/85.6%). The IVP group was statistically non-inferior to the CP group, and on various assessment days, statistical superiority was proven for flea and tick count reduction in dogs and cats. Both treatments proved to be safe in dogs and cats with mainly minor local observations at the application site. There was moreover, no incidence of any mechanical problem with the collar in dogs and cats during the entire study period.</p> <p>Conclusions</p> <p>The imidacloprid/flumethrin collar proved to reduce tick counts by at least 90% and flea counts by at least 95% for a period of at least 7-8 months in cats and dogs under field conditions. Therefore, it can be used as sustainable long-term preventative, covering the whole flea and tick season.</p> |
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| institution | Directory Open Access Journal |
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| last_indexed | 2024-12-19T08:37:34Z |
| publishDate | 2012-03-01 |
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| spelling | doaj.art-423555d1b85d4936ba81d0db4716c9f22022-12-21T20:29:01ZengBMCParasites & Vectors1756-33052012-03-01516610.1186/1756-3305-5-66Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in EuropeStanneck DorotheeRass JuliaRadeloff IsabelKruedewagen EvaLe Sueur ChristopheHellmann KlausKrieger Klemens<p>Abstract</p> <p>Background</p> <p>The objective of these two GCP multicentre European clinical field studies was to evaluate the long-term efficacy and safety of a new imidacloprid/flumethrin collar (Seresto<sup>®</sup>, Bayer AnimalHealth, Investigational Veterinary Product(IVP)) in dogs and cats naturally infested with fleas and/or ticks in comparison to a dimpylat collar ("Ungezieferband fuer Hunde/fuer Katzen", Beaphar, Control Product (CP)).</p> <p>Methods</p> <p>232 (IVP) and 81 (CP) cats and 271(IVP) and 129 (CP) dogs were treated with either product according to label claims and formed the safety population. Flea and tick counts were conducted in monthly intervals for up to 8 months in the efficacy subpopulation consisting of 118 (IVP) + 47 (CP) cats and 197 (IVP) + 94 (CP) dogs. Efficacy was calculated as reduction of infestation rate within the same treatment group and statistically compared between the two treatment groups.</p> <p>Results</p> <p>Preventive efficacy against fleas in cats/dogs varied in the IVP group between 97.4%/94.1% and 100%/100% (overall mean: 98.3%/96.7%) throughout the 8 month period and in the CP group between 57.1%/28.2% and 96.1%/67.8% (overall mean: 79.3%/57.9%). Preventive efficacy against ticks in cats/dogs varied in the IVP group between 94.0%/91.2% and 100%/100% (overall mean: 98.4%/94.7%) throughout the 8 month period and in the CP group between 90.7%/79.9% and 100%/88.0% (overall mean: 96.9%/85.6%). The IVP group was statistically non-inferior to the CP group, and on various assessment days, statistical superiority was proven for flea and tick count reduction in dogs and cats. Both treatments proved to be safe in dogs and cats with mainly minor local observations at the application site. There was moreover, no incidence of any mechanical problem with the collar in dogs and cats during the entire study period.</p> <p>Conclusions</p> <p>The imidacloprid/flumethrin collar proved to reduce tick counts by at least 90% and flea counts by at least 95% for a period of at least 7-8 months in cats and dogs under field conditions. Therefore, it can be used as sustainable long-term preventative, covering the whole flea and tick season.</p>http://www.parasitesandvectors.com/content/5/1/66<it>Ctenocephalides felis</it><it>Ctenocephalides canis</it><it>Archaeopsylla erinacei</it><it>Pulex irritans</it><it>Dermacentor reticulatus</it><it>Ixodes hexagonus</it><it>Ixodes ricinus</it>FleasTicksEfficacySafetyImidaclopridFlumethrinCollarField |
| spellingShingle | Stanneck Dorothee Rass Julia Radeloff Isabel Kruedewagen Eva Le Sueur Christophe Hellmann Klaus Krieger Klemens Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe Parasites & Vectors <it>Ctenocephalides felis</it> <it>Ctenocephalides canis</it> <it>Archaeopsylla erinacei</it> <it>Pulex irritans</it> <it>Dermacentor reticulatus</it> <it>Ixodes hexagonus</it> <it>Ixodes ricinus</it> Fleas Ticks Efficacy Safety Imidacloprid Flumethrin Collar Field |
| title | Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe |
| title_full | Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe |
| title_fullStr | Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe |
| title_full_unstemmed | Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe |
| title_short | Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto<sup>®</sup>) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe |
| title_sort | evaluation of the long term efficacy and safety of an imidacloprid 10 flumethrin 4 5 polymer matrix collar seresto sup r sup in dogs and cats naturally infested with fleas and or ticks in multicentre clinical field studies in europe |
| topic | <it>Ctenocephalides felis</it> <it>Ctenocephalides canis</it> <it>Archaeopsylla erinacei</it> <it>Pulex irritans</it> <it>Dermacentor reticulatus</it> <it>Ixodes hexagonus</it> <it>Ixodes ricinus</it> Fleas Ticks Efficacy Safety Imidacloprid Flumethrin Collar Field |
| url | http://www.parasitesandvectors.com/content/5/1/66 |
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