Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features

Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features

Abstract Background The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate immune cells. The precise mechanism(s) by which immunoglobulin G...

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Bibliographic Details
Main Authors: Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Retrovirology
Subjects:
IgG
Antibody
Effector function
HIV
Vaccine
Online Access:https://doi.org/10.1186/s12977-021-00579-9

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