Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion

Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion

Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response named the Unfolded Protein Response (UPR), leading to protein translation rep...

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Bibliographic Details
Main Authors: Celia Maria Limia, Chloé Sauzay, Hery Urra, Claudio Hetz, Eric Chevet, Tony Avril
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
cancer
cell invasion
cell migration
ER stress
IRE1
PERK
ATF6
Online Access:https://www.mdpi.com/2072-6694/11/5/631

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