Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia
Background: The aim of this study was to evaluate the effect of preemptive methadone or paracetamol on postoperative pain in lower abdomen surgery under general anesthesia in comparison with control group. Methods: This was a randomized clinical trial study on 96 patients undergoing lower abdominal...
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| Format: | Article |
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Isfahan University of Medical Sciences
2018-02-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/8877 |
| _version_ | 1797762037934194688 |
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| author | Gholamreza Khalili Seyed Taghi Hashemi Zakieh Abdollahi |
| author_facet | Gholamreza Khalili Seyed Taghi Hashemi Zakieh Abdollahi |
| author_sort | Gholamreza Khalili |
| collection | DOAJ |
| description | Background: The aim of this study was to evaluate the effect of preemptive methadone or paracetamol on postoperative pain in lower abdomen surgery under general anesthesia in comparison with control group.
Methods: This was a randomized clinical trial study on 96 patients undergoing lower abdominal surgery. The subjects were divided into three groups. In the first group, 15 mg intravenous paracetamol was injected gradually after anesthesia induction and before surgery. In the second group, 0.15 mg/kg intramuscular methadone was injected into patient's deltoid muscle before anesthesia induction. In the third group, same volume of normal saline was injected. Then, pain intensity were evaluated in all three groups in recovery and ward up to 24 hours using visual analog scale (VAS).
Findings: Pain intensity at 30 minutes after the surgery in the paracetamol group with a mean of 0.73 ± 0.31 was significantly lower than methadone group with a mean of 2.53 ± 0.54; and in both groups received the drugs was significantly lower than control group with a mean of 2.97 ± 0.57 (P < 0.050 for all). In contrast, since 60 minutes after the surgery to discharge time and in the ward, after 4 to 24 hours, pain intensity did not differ significantly between the three groups (P > 0.050).
Conclusion: According our results, preemptive methadone had a much better effect in controlling postoperative pain compared to preemptive paracetamol; however, complications of paracetamol were less than methadone. Finally, pain intensity was evaluated equal in two groups for up to 24 hours after the surgery. |
| first_indexed | 2024-03-12T19:21:41Z |
| format | Article |
| id | doaj.art-42388a2052594290a7cb0ebbc1914f6d |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:21:41Z |
| publishDate | 2018-02-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-42388a2052594290a7cb0ebbc1914f6d2023-08-02T05:06:38ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2018-02-01354611845185110.22122/jims.v35i461.88772777Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General AnesthesiaGholamreza Khalili0Seyed Taghi Hashemi1Zakieh Abdollahi2Associate Professor, Department of Anesthesiology, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: The aim of this study was to evaluate the effect of preemptive methadone or paracetamol on postoperative pain in lower abdomen surgery under general anesthesia in comparison with control group. Methods: This was a randomized clinical trial study on 96 patients undergoing lower abdominal surgery. The subjects were divided into three groups. In the first group, 15 mg intravenous paracetamol was injected gradually after anesthesia induction and before surgery. In the second group, 0.15 mg/kg intramuscular methadone was injected into patient's deltoid muscle before anesthesia induction. In the third group, same volume of normal saline was injected. Then, pain intensity were evaluated in all three groups in recovery and ward up to 24 hours using visual analog scale (VAS). Findings: Pain intensity at 30 minutes after the surgery in the paracetamol group with a mean of 0.73 ± 0.31 was significantly lower than methadone group with a mean of 2.53 ± 0.54; and in both groups received the drugs was significantly lower than control group with a mean of 2.97 ± 0.57 (P < 0.050 for all). In contrast, since 60 minutes after the surgery to discharge time and in the ward, after 4 to 24 hours, pain intensity did not differ significantly between the three groups (P > 0.050). Conclusion: According our results, preemptive methadone had a much better effect in controlling postoperative pain compared to preemptive paracetamol; however, complications of paracetamol were less than methadone. Finally, pain intensity was evaluated equal in two groups for up to 24 hours after the surgery.http://jims.mui.ac.ir/index.php/jims/article/view/8877MethadoneParacetamolPainAbdomen Surgery |
| spellingShingle | Gholamreza Khalili Seyed Taghi Hashemi Zakieh Abdollahi Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia مجله دانشکده پزشکی اصفهان Methadone Paracetamol Pain Abdomen Surgery |
| title | Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia |
| title_full | Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia |
| title_fullStr | Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia |
| title_full_unstemmed | Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia |
| title_short | Impact of Preemptive Methadone or Paracetamol in Controlling Pain after Lower Abdomen Surgery under General Anesthesia |
| title_sort | impact of preemptive methadone or paracetamol in controlling pain after lower abdomen surgery under general anesthesia |
| topic | Methadone Paracetamol Pain Abdomen Surgery |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/8877 |
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