Vascularized Tissue Organoids
Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/10/2/124 |
| _version_ | 1797622336959021056 |
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| author | Hannah A. Strobel Sarah M. Moss James B. Hoying |
| author_facet | Hannah A. Strobel Sarah M. Moss James B. Hoying |
| author_sort | Hannah A. Strobel |
| collection | DOAJ |
| description | Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature also contributes to the cellular dynamics of the tissue model via the cells of the perivascular niche, thereby further modulating tissue function. In this review, we discuss current and developing strategies for vascularizing organoids, consider tissue-specific vascularization approaches, discuss the importance of perfusion, and provide perspectives on the state of the field. |
| first_indexed | 2024-03-11T09:08:48Z |
| format | Article |
| id | doaj.art-4238e6dd6ec94e368d9256fd1a5e18ce |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T09:08:48Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-4238e6dd6ec94e368d9256fd1a5e18ce2023-11-16T19:09:54ZengMDPI AGBioengineering2306-53542023-01-0110212410.3390/bioengineering10020124Vascularized Tissue OrganoidsHannah A. Strobel0Sarah M. Moss1James B. Hoying2Advanced Solutions Life Sciences, Manchester, NH 03101, USAAdvanced Solutions Life Sciences, Manchester, NH 03101, USAAdvanced Solutions Life Sciences, Manchester, NH 03101, USATissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature also contributes to the cellular dynamics of the tissue model via the cells of the perivascular niche, thereby further modulating tissue function. In this review, we discuss current and developing strategies for vascularizing organoids, consider tissue-specific vascularization approaches, discuss the importance of perfusion, and provide perspectives on the state of the field.https://www.mdpi.com/2306-5354/10/2/124organoidvascularizationspheroidstem cellmicrovesselvessel |
| spellingShingle | Hannah A. Strobel Sarah M. Moss James B. Hoying Vascularized Tissue Organoids Bioengineering organoid vascularization spheroid stem cell microvessel vessel |
| title | Vascularized Tissue Organoids |
| title_full | Vascularized Tissue Organoids |
| title_fullStr | Vascularized Tissue Organoids |
| title_full_unstemmed | Vascularized Tissue Organoids |
| title_short | Vascularized Tissue Organoids |
| title_sort | vascularized tissue organoids |
| topic | organoid vascularization spheroid stem cell microvessel vessel |
| url | https://www.mdpi.com/2306-5354/10/2/124 |
| work_keys_str_mv | AT hannahastrobel vascularizedtissueorganoids AT sarahmmoss vascularizedtissueorganoids AT jamesbhoying vascularizedtissueorganoids |