Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function

Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function

Objective: Genetic and acquired abnormalities contribute to pancreatic β-cell failure in diabetes. Transcription factors Hnf4α (MODY1) and FoxO1 are respective examples of these two components and act through β-cell-specific enhancers. However, their relationship is unclear. Methods: In this report,...

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Bibliographic Details
Main Authors: Taiyi Kuo, Wen Du, Yasutaka Miyachi, Prasanna K. Dadi, David A. Jacobson, Daniel Segrè, Domenico Accili
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Beta cell
Hnf4a
Foxo1
Enhancer
Insulin
Epistasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001010

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