Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children
ObjectivesTo study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors.MethodologyThis study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.817613/full |
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| author | Sixian Lao Sixian Lao Tao Zhou Ho-Chang Kuo Ho-Chang Kuo Guoping Zhong Guoping Zhong Weiwei Zeng Weiwei Zeng |
| author_facet | Sixian Lao Sixian Lao Tao Zhou Ho-Chang Kuo Ho-Chang Kuo Guoping Zhong Guoping Zhong Weiwei Zeng Weiwei Zeng |
| author_sort | Sixian Lao |
| collection | DOAJ |
| description | ObjectivesTo study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors.MethodologyThis study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, and a no-coronary artery lesions (NCAL) group, and stratified by the use of antibiotics. We collected clinical and laboratory data before the intravenous immunoglobulin (IVIG) treatment.ResultsThe two groups of KD patients with and without CAL were compared. The results showed that there are significant differences between groups which were erythrocyte count (p = 0.045) and hemoglobin (p = 0.005), red blood cell-specific volume (p = 0.001), immature granular cells percentage (p = 0.006), total protein (p = 0.045), albumin (p = 0.041), alkaline phosphatase (p = 0.023), and chlorine (p = 0.006). After multivariate logistic regression, neutrophil granulocyte percentage (odds ratio [OR] = 1.200, 95% confidence interval [CI]: 1.008-1.428, p = 0.040), lymphocyte percentage (p = 0.028, OR = 1.243, 95% CI: 1.024-1.508, p = 0.028) and total protein (OR = 4.414, 95% CI: 1.092-17.846, p = 0.037) were found to be independent risk factors for CAL. After analyzing the cases with a history of antibiotic use, multivariate analysis showed no indicators were considered independent risk factors for CAL.ConclusionNeutrophil granulocyte percentage, Lymphocyte percentage and total protein were independent risks for CAL in KD without antibiotics use history. The use of antibiotics affected physiological indicators of KD patients. |
| first_indexed | 2024-04-12T11:41:46Z |
| format | Article |
| id | doaj.art-423a12f8b2294cb1849aca361eaf0f42 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T11:41:46Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-423a12f8b2294cb1849aca361eaf0f422022-12-22T03:34:36ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-05-011010.3389/fpubh.2022.817613817613Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese ChildrenSixian Lao0Sixian Lao1Tao Zhou2Ho-Chang Kuo3Ho-Chang Kuo4Guoping Zhong5Guoping Zhong6Weiwei Zeng7Weiwei Zeng8Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, ChinaShenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, ChinaKawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanInstitute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, ChinaThe Second People's Hospital of Longgang District, Shenzhen, ChinaShenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, ChinaObjectivesTo study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors.MethodologyThis study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, and a no-coronary artery lesions (NCAL) group, and stratified by the use of antibiotics. We collected clinical and laboratory data before the intravenous immunoglobulin (IVIG) treatment.ResultsThe two groups of KD patients with and without CAL were compared. The results showed that there are significant differences between groups which were erythrocyte count (p = 0.045) and hemoglobin (p = 0.005), red blood cell-specific volume (p = 0.001), immature granular cells percentage (p = 0.006), total protein (p = 0.045), albumin (p = 0.041), alkaline phosphatase (p = 0.023), and chlorine (p = 0.006). After multivariate logistic regression, neutrophil granulocyte percentage (odds ratio [OR] = 1.200, 95% confidence interval [CI]: 1.008-1.428, p = 0.040), lymphocyte percentage (p = 0.028, OR = 1.243, 95% CI: 1.024-1.508, p = 0.028) and total protein (OR = 4.414, 95% CI: 1.092-17.846, p = 0.037) were found to be independent risk factors for CAL. After analyzing the cases with a history of antibiotic use, multivariate analysis showed no indicators were considered independent risk factors for CAL.ConclusionNeutrophil granulocyte percentage, Lymphocyte percentage and total protein were independent risks for CAL in KD without antibiotics use history. The use of antibiotics affected physiological indicators of KD patients.https://www.frontiersin.org/articles/10.3389/fpubh.2022.817613/fullKawasaki diseasecoronary artery lesionsrisk factorsantibioticschildren |
| spellingShingle | Sixian Lao Sixian Lao Tao Zhou Ho-Chang Kuo Ho-Chang Kuo Guoping Zhong Guoping Zhong Weiwei Zeng Weiwei Zeng Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children Frontiers in Public Health Kawasaki disease coronary artery lesions risk factors antibiotics children |
| title | Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children |
| title_full | Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children |
| title_fullStr | Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children |
| title_full_unstemmed | Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children |
| title_short | Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children |
| title_sort | risk factors for coronary artery lesionsin kawasaki disease independent of antibiotic use in chinese children |
| topic | Kawasaki disease coronary artery lesions risk factors antibiotics children |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.817613/full |
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