Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle
Atrial fibrillation, the most frequent arrhythmia in clinical practice and chronic coronary syndrome, is one of the forms of coronary ischemia to have a strong dual relationship. Atrial fibrillation may accelerate atherosclerosis and may increase oxygen consumption in the myocardium, creating a mism...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/6/1370 |
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| author | Alexandru Florinel Oancea Raul Alexandru Jigoranu Paula Cristina Morariu Radu-Stefan Miftode Bogdan Andrei Trandabat Diana Elena Iov Elena Cojocaru Irina Iuliana Costache Livia Genoveva Baroi Daniel Vasile Timofte Daniela Maria Tanase Mariana Floria |
| author_facet | Alexandru Florinel Oancea Raul Alexandru Jigoranu Paula Cristina Morariu Radu-Stefan Miftode Bogdan Andrei Trandabat Diana Elena Iov Elena Cojocaru Irina Iuliana Costache Livia Genoveva Baroi Daniel Vasile Timofte Daniela Maria Tanase Mariana Floria |
| author_sort | Alexandru Florinel Oancea |
| collection | DOAJ |
| description | Atrial fibrillation, the most frequent arrhythmia in clinical practice and chronic coronary syndrome, is one of the forms of coronary ischemia to have a strong dual relationship. Atrial fibrillation may accelerate atherosclerosis and may increase oxygen consumption in the myocardium, creating a mismatch between supply and demand, thus promoting the development or worsening of coronary ischemia. Chronic coronary syndrome alters the structure and function of gap junction proteins, affecting the conduction of action potential and leading to ischemic necrosis of cardiomyocytes and their replacement with fibrous tissue, in this way sustaining the focal ectopic activity in atrial myocardium. They have many risk factors in common, such as hypertension, obesity, type 2 diabetes mellitus, and dyslipidemia. It is vital for the prognosis of patients to break this vicious circle by controlling risk factors, drug therapies, of which antithrombotic therapy may sometimes be challenging in terms of prothrombotic and bleeding risk, and interventional therapies (revascularization and catheter ablation). |
| first_indexed | 2024-03-11T02:14:18Z |
| format | Article |
| id | doaj.art-423e2d7f19f149de8e5e908a91e24bd2 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T02:14:18Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-423e2d7f19f149de8e5e908a91e24bd22023-11-18T11:18:21ZengMDPI AGLife2075-17292023-06-01136137010.3390/life13061370Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious CircleAlexandru Florinel Oancea0Raul Alexandru Jigoranu1Paula Cristina Morariu2Radu-Stefan Miftode3Bogdan Andrei Trandabat4Diana Elena Iov5Elena Cojocaru6Irina Iuliana Costache7Livia Genoveva Baroi8Daniel Vasile Timofte9Daniela Maria Tanase10Mariana Floria11Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, RomaniaAtrial fibrillation, the most frequent arrhythmia in clinical practice and chronic coronary syndrome, is one of the forms of coronary ischemia to have a strong dual relationship. Atrial fibrillation may accelerate atherosclerosis and may increase oxygen consumption in the myocardium, creating a mismatch between supply and demand, thus promoting the development or worsening of coronary ischemia. Chronic coronary syndrome alters the structure and function of gap junction proteins, affecting the conduction of action potential and leading to ischemic necrosis of cardiomyocytes and their replacement with fibrous tissue, in this way sustaining the focal ectopic activity in atrial myocardium. They have many risk factors in common, such as hypertension, obesity, type 2 diabetes mellitus, and dyslipidemia. It is vital for the prognosis of patients to break this vicious circle by controlling risk factors, drug therapies, of which antithrombotic therapy may sometimes be challenging in terms of prothrombotic and bleeding risk, and interventional therapies (revascularization and catheter ablation).https://www.mdpi.com/2075-1729/13/6/1370coronary ischemiacoronary artery diseaseatrial fibrillationchronic coronary syndrometriple antithrombotic therapy |
| spellingShingle | Alexandru Florinel Oancea Raul Alexandru Jigoranu Paula Cristina Morariu Radu-Stefan Miftode Bogdan Andrei Trandabat Diana Elena Iov Elena Cojocaru Irina Iuliana Costache Livia Genoveva Baroi Daniel Vasile Timofte Daniela Maria Tanase Mariana Floria Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle Life coronary ischemia coronary artery disease atrial fibrillation chronic coronary syndrome triple antithrombotic therapy |
| title | Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle |
| title_full | Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle |
| title_fullStr | Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle |
| title_full_unstemmed | Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle |
| title_short | Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle |
| title_sort | atrial fibrillation and chronic coronary ischemia a challenging vicious circle |
| topic | coronary ischemia coronary artery disease atrial fibrillation chronic coronary syndrome triple antithrombotic therapy |
| url | https://www.mdpi.com/2075-1729/13/6/1370 |
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