Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies
Prenatal exposure to valproate (VPA), an antiepileptic drug, has been associated with fetal valproate spectrum disorders (FVSD), a clinical condition including congenital malformations, developmental delay, intellectual disability as well as autism spectrum disorder, together with a distinctive faci...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.654467/full |
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| author | Chiara Parodi Elisabetta Di Fede Angela Peron Angela Peron Angela Peron Ilaria Viganò Paolo Grazioli Silvia Castiglioni Richard H. Finnell Cristina Gervasini Cristina Gervasini Aglaia Vignoli Valentina Massa Valentina Massa |
| author_facet | Chiara Parodi Elisabetta Di Fede Angela Peron Angela Peron Angela Peron Ilaria Viganò Paolo Grazioli Silvia Castiglioni Richard H. Finnell Cristina Gervasini Cristina Gervasini Aglaia Vignoli Valentina Massa Valentina Massa |
| author_sort | Chiara Parodi |
| collection | DOAJ |
| description | Prenatal exposure to valproate (VPA), an antiepileptic drug, has been associated with fetal valproate spectrum disorders (FVSD), a clinical condition including congenital malformations, developmental delay, intellectual disability as well as autism spectrum disorder, together with a distinctive facial appearance. VPA is a known inhibitor of histone deacetylase which regulates the chromatin state. Interestingly, perturbations of this epigenetic balance are associated with chromatinopathies, a heterogeneous group of Mendelian disorders arising from mutations in components of the epigenetic machinery. Patients affected from these disorders display a plethora of clinical signs, mainly neurological deficits and intellectual disability, together with distinctive craniofacial dysmorphisms. Remarkably, critically examining the phenotype of FVSD and chromatinopathies, they shared several overlapping features that can be observed despite the different etiologies of these disorders, suggesting the possible existence of a common perturbed mechanism(s) during embryonic development. |
| first_indexed | 2024-12-20T08:38:36Z |
| format | Article |
| id | doaj.art-423ff3c34b9142c2bb09adabb7f90ee0 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-20T08:38:36Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-423ff3c34b9142c2bb09adabb7f90ee02022-12-21T19:46:27ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-04-01910.3389/fcell.2021.654467654467Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and ChromatinopathiesChiara Parodi0Elisabetta Di Fede1Angela Peron2Angela Peron3Angela Peron4Ilaria Viganò5Paolo Grazioli6Silvia Castiglioni7Richard H. Finnell8Cristina Gervasini9Cristina Gervasini10Aglaia Vignoli11Valentina Massa12Valentina Massa13Department of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyHuman Pathology and Medical Genetics, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan, ItalyChild Neuropsychiatry Unit–Epilepsy Center, Department of Health Sciences, San Paolo Hospital, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Milan, ItalyDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, United StatesDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartments of Molecular and Cellular Biology, Molecular and Human Genetics and Medicine, Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, United StatesDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy“Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy“Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, ItalyPrenatal exposure to valproate (VPA), an antiepileptic drug, has been associated with fetal valproate spectrum disorders (FVSD), a clinical condition including congenital malformations, developmental delay, intellectual disability as well as autism spectrum disorder, together with a distinctive facial appearance. VPA is a known inhibitor of histone deacetylase which regulates the chromatin state. Interestingly, perturbations of this epigenetic balance are associated with chromatinopathies, a heterogeneous group of Mendelian disorders arising from mutations in components of the epigenetic machinery. Patients affected from these disorders display a plethora of clinical signs, mainly neurological deficits and intellectual disability, together with distinctive craniofacial dysmorphisms. Remarkably, critically examining the phenotype of FVSD and chromatinopathies, they shared several overlapping features that can be observed despite the different etiologies of these disorders, suggesting the possible existence of a common perturbed mechanism(s) during embryonic development.https://www.frontiersin.org/articles/10.3389/fcell.2021.654467/fullfetal valproate syndromechromatinopathiesanti-epileptic drugsneurodevelopmentHDAC inhibitor |
| spellingShingle | Chiara Parodi Elisabetta Di Fede Angela Peron Angela Peron Angela Peron Ilaria Viganò Paolo Grazioli Silvia Castiglioni Richard H. Finnell Cristina Gervasini Cristina Gervasini Aglaia Vignoli Valentina Massa Valentina Massa Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies Frontiers in Cell and Developmental Biology fetal valproate syndrome chromatinopathies anti-epileptic drugs neurodevelopment HDAC inhibitor |
| title | Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies |
| title_full | Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies |
| title_fullStr | Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies |
| title_full_unstemmed | Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies |
| title_short | Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies |
| title_sort | chromatin imbalance as the vertex between fetal valproate syndrome and chromatinopathies |
| topic | fetal valproate syndrome chromatinopathies anti-epileptic drugs neurodevelopment HDAC inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.654467/full |
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