Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts

Abstract Background Previous studies indicate that soyasaponins may reduce inflammation via modulating toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling. However, its underlying mechanisms are still not fully understood. Methods Lipopolysaccharide (LPS)-challenged infla...

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Bibliographic Details
Main Authors: Junbin Chen, Hidayat Ullah, Zhongdaixi Zheng, Xiangfu Gu, Chuhong Su, Lingyu Xiao, Xinglong Wu, Fei Xiong, Qing Li, Longying Zha
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Soyasaponin
Toll-like receptor 4 (TLR4)
Myeloid differentiation factor 88 (MyD88)
Inflammation
Lipid raft
Online Access:http://link.springer.com/article/10.1186/s12906-020-2864-2

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