Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil
Age-related seroprevalence studies that have been conducted in Brazil have indicated a transition from a high to a medium endemicity of hepatitis A virus (HAV) infection in the population. However, most of these studies have focused on urban populations that experience lower incidence rates of HAV i...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2012-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500012&lng=en&tlng=en |
| _version_ | 1797718070337208320 |
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| author | Claudia Lamarca Vitral Fidel Leonardo Navarro Ospina Solange Artimos Juliana Gil Melgaço Oswaldo Gonçalves Cruz Vanessa Salete de Paula Sérgio Bessa Luz Marcos Freire Luciane Pinto Gaspar Luciane Almeida Amado Elyne Montenegro Engstrom Camila Dufrayer Fanzeres Monteiro Fortes Tayla Coleta de Souza Marisa Nishitani Dias Ana Maria Coimbra Gaspar Francisco José Dutra Souto |
| author_facet | Claudia Lamarca Vitral Fidel Leonardo Navarro Ospina Solange Artimos Juliana Gil Melgaço Oswaldo Gonçalves Cruz Vanessa Salete de Paula Sérgio Bessa Luz Marcos Freire Luciane Pinto Gaspar Luciane Almeida Amado Elyne Montenegro Engstrom Camila Dufrayer Fanzeres Monteiro Fortes Tayla Coleta de Souza Marisa Nishitani Dias Ana Maria Coimbra Gaspar Francisco José Dutra Souto |
| author_sort | Claudia Lamarca Vitral |
| collection | DOAJ |
| description | Age-related seroprevalence studies that have been conducted in Brazil have indicated a transition from a high to a medium endemicity of hepatitis A virus (HAV) infection in the population. However, most of these studies have focused on urban populations that experience lower incidence rates of HAV infection. In the current study, the prevalence of anti-HAV antibodies was investigated in children with a low socioeconomic status (SES) that live on the periphery of three capital cities in Brazil. A total of 1,162 dried blood spot samples were collected from individuals whose ages ranged from one-18 years and tested for anti-HAV antibodies. A large number of children under five years old (74.1-90%) were identified to be susceptible to HAV infection. The anti-HAV antibody prevalence reached ≥ 50% among those that were 10-14 years of age or older. The anti-HAV prevalence rates observed were characteristics of regions with intermediate level of hepatitis A endemicity. These data indicated that a large proportion of children with a low SES that live at the periphery of urban cities might be at risk of contracting an HAV infection. The hepatitis A vaccine that is currently offered in Brazil is only available for high-risk groups or at private clinics and is unaffordable for individuals with a lower SES. The results from this study suggest that the hepatitis A vaccine should be included in the Brazilian National Program for Immunisation. |
| first_indexed | 2024-03-12T08:45:40Z |
| format | Article |
| id | doaj.art-42427e47170644fa8d13bfc37b5076d3 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:45:40Z |
| publishDate | 2012-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-42427e47170644fa8d13bfc37b5076d32023-09-02T16:28:28ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-08-01107565265810.1590/S0074-02762012000500012S0074-02762012000500012Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in BrazilClaudia Lamarca Vitral0Fidel Leonardo Navarro Ospina1Solange Artimos2Juliana Gil Melgaço3Oswaldo Gonçalves Cruz4Vanessa Salete de Paula5Sérgio Bessa Luz6Marcos Freire7Luciane Pinto Gaspar8Luciane Almeida Amado9Elyne Montenegro Engstrom10Camila Dufrayer Fanzeres Monteiro Fortes11Tayla Coleta de Souza12Marisa Nishitani Dias13Ana Maria Coimbra Gaspar14Francisco José Dutra Souto15Universidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseFundação Oswaldo CruzUniversidade Federal FluminenseFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzUniversidade Federal FluminenseFundação Oswaldo CruzUniversidade Federal de Mato GrossoUniversidade Federal de Mato GrossoSecretaria de Saúde do MunicípioUniversidade Federal FluminenseUniversidade Federal de Mato GrossoAge-related seroprevalence studies that have been conducted in Brazil have indicated a transition from a high to a medium endemicity of hepatitis A virus (HAV) infection in the population. However, most of these studies have focused on urban populations that experience lower incidence rates of HAV infection. In the current study, the prevalence of anti-HAV antibodies was investigated in children with a low socioeconomic status (SES) that live on the periphery of three capital cities in Brazil. A total of 1,162 dried blood spot samples were collected from individuals whose ages ranged from one-18 years and tested for anti-HAV antibodies. A large number of children under five years old (74.1-90%) were identified to be susceptible to HAV infection. The anti-HAV antibody prevalence reached ≥ 50% among those that were 10-14 years of age or older. The anti-HAV prevalence rates observed were characteristics of regions with intermediate level of hepatitis A endemicity. These data indicated that a large proportion of children with a low SES that live at the periphery of urban cities might be at risk of contracting an HAV infection. The hepatitis A vaccine that is currently offered in Brazil is only available for high-risk groups or at private clinics and is unaffordable for individuals with a lower SES. The results from this study suggest that the hepatitis A vaccine should be included in the Brazilian National Program for Immunisation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500012&lng=en&tlng=enhepatitis AepidemiologyBrazilprevalencehepatitis A vaccines |
| spellingShingle | Claudia Lamarca Vitral Fidel Leonardo Navarro Ospina Solange Artimos Juliana Gil Melgaço Oswaldo Gonçalves Cruz Vanessa Salete de Paula Sérgio Bessa Luz Marcos Freire Luciane Pinto Gaspar Luciane Almeida Amado Elyne Montenegro Engstrom Camila Dufrayer Fanzeres Monteiro Fortes Tayla Coleta de Souza Marisa Nishitani Dias Ana Maria Coimbra Gaspar Francisco José Dutra Souto Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil Memorias do Instituto Oswaldo Cruz hepatitis A epidemiology Brazil prevalence hepatitis A vaccines |
| title | Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil |
| title_full | Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil |
| title_fullStr | Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil |
| title_full_unstemmed | Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil |
| title_short | Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil |
| title_sort | declining prevalence of hepatitis a virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis a vaccination in brazil |
| topic | hepatitis A epidemiology Brazil prevalence hepatitis A vaccines |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500012&lng=en&tlng=en |
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