Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction.
Post-stroke cognitive dysfunction greatly influences patients' quality of life after stroke. However, its neurophysiological basis remains unknown. This study utilized resting-state functional magnetic resonance imaging (fMRI) to investigate the alterations in regional coherence in patients aft...
| Prif Awduron: | , , , , , , , |
|---|---|
| Fformat: | Erthygl |
| Iaith: | English |
| Cyhoeddwyd: |
Public Library of Science (PLoS)
2016-01-01
|
| Cyfres: | PLoS ONE |
| Mynediad Ar-lein: | http://europepmc.org/articles/PMC4959733?pdf=render |
| _version_ | 1828308498239193088 |
|---|---|
| author | Cheng-Yu Peng Yu-Chen Chen Ying Cui Deng-Ling Zhao Yun Jiao Tian-Yu Tang Shenghong Ju Gao-Jun Teng |
| author_facet | Cheng-Yu Peng Yu-Chen Chen Ying Cui Deng-Ling Zhao Yun Jiao Tian-Yu Tang Shenghong Ju Gao-Jun Teng |
| author_sort | Cheng-Yu Peng |
| collection | DOAJ |
| description | Post-stroke cognitive dysfunction greatly influences patients' quality of life after stroke. However, its neurophysiological basis remains unknown. This study utilized resting-state functional magnetic resonance imaging (fMRI) to investigate the alterations in regional coherence in patients after subcortical stroke.Resting-state fMRI measurements were acquired from 16 post-stroke patients with poor cognitive function (PSPC), 16 post-stroke patients with good cognitive function (PSGC) and 30 well-matched healthy controls (HC). Regional homogeneity (ReHo) was used to detect alterations in regional coherence. Abnormalities in regional coherence correlated with scores on neuropsychological scales.Compared to the HC and the PSGC, the PSPC showed remarkably decreased ReHo in the bilateral anterior cingulate cortex and the left posterior cingulate cortex/precuneus. ReHo in the bilateral anterior cingulate cortex positively correlated with the scores on the Symbol Digit Modalities Test (r = 0.399, P = 0.036) and the Complex Figure Test-delayed recall subtest (r = 0.397, P = 0.036) in all post-stroke patients. Moreover, ReHo in the left posterior cingulate cortex/precuneus positively correlated with the scores on the Forward Digit Span Test (r = 0.485, P = 0.009) in all post-stroke patients.Aberrant regional coherence was observed in the anterior and posterior cingulate cortices in post-stroke patients with cognitive dysfunction. ReHo could represent a promising indicator of neurobiological deficiencies in post-stroke patients. |
| first_indexed | 2024-04-13T15:14:17Z |
| format | Article |
| id | doaj.art-4243f6482bde4309bd69e6c0a42ee738 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T15:14:17Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4243f6482bde4309bd69e6c0a42ee7382022-12-22T02:41:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01117e015957410.1371/journal.pone.0159574Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction.Cheng-Yu PengYu-Chen ChenYing CuiDeng-Ling ZhaoYun JiaoTian-Yu TangShenghong JuGao-Jun TengPost-stroke cognitive dysfunction greatly influences patients' quality of life after stroke. However, its neurophysiological basis remains unknown. This study utilized resting-state functional magnetic resonance imaging (fMRI) to investigate the alterations in regional coherence in patients after subcortical stroke.Resting-state fMRI measurements were acquired from 16 post-stroke patients with poor cognitive function (PSPC), 16 post-stroke patients with good cognitive function (PSGC) and 30 well-matched healthy controls (HC). Regional homogeneity (ReHo) was used to detect alterations in regional coherence. Abnormalities in regional coherence correlated with scores on neuropsychological scales.Compared to the HC and the PSGC, the PSPC showed remarkably decreased ReHo in the bilateral anterior cingulate cortex and the left posterior cingulate cortex/precuneus. ReHo in the bilateral anterior cingulate cortex positively correlated with the scores on the Symbol Digit Modalities Test (r = 0.399, P = 0.036) and the Complex Figure Test-delayed recall subtest (r = 0.397, P = 0.036) in all post-stroke patients. Moreover, ReHo in the left posterior cingulate cortex/precuneus positively correlated with the scores on the Forward Digit Span Test (r = 0.485, P = 0.009) in all post-stroke patients.Aberrant regional coherence was observed in the anterior and posterior cingulate cortices in post-stroke patients with cognitive dysfunction. ReHo could represent a promising indicator of neurobiological deficiencies in post-stroke patients.http://europepmc.org/articles/PMC4959733?pdf=render |
| spellingShingle | Cheng-Yu Peng Yu-Chen Chen Ying Cui Deng-Ling Zhao Yun Jiao Tian-Yu Tang Shenghong Ju Gao-Jun Teng Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. PLoS ONE |
| title | Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. |
| title_full | Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. |
| title_fullStr | Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. |
| title_full_unstemmed | Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. |
| title_short | Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. |
| title_sort | regional coherence alterations revealed by resting state fmri in post stroke patients with cognitive dysfunction |
| url | http://europepmc.org/articles/PMC4959733?pdf=render |
| work_keys_str_mv | AT chengyupeng regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT yuchenchen regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT yingcui regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT denglingzhao regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT yunjiao regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT tianyutang regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT shenghongju regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction AT gaojunteng regionalcoherencealterationsrevealedbyrestingstatefmriinpoststrokepatientswithcognitivedysfunction |