AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity

AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity

Type 2 diabetes, insulin resistance, and obesity are strongly associated and are a major health problem worldwide. Obesity largely results from a sustained imbalance between energy intake and expenditure. Therapeutic approaches targeting metabolic rate may counteract body weight gain and insulin res...

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Bibliographic Details
Main Authors: Estefania Casana, Veronica Jimenez, Claudia Jambrina, Victor Sacristan, Sergio Muñoz, Jordi Rodo, Ignasi Grass, Miquel Garcia, Cristina Mallol, Xavier León, Alba Casellas, Víctor Sánchez, Sylvie Franckhauser, Tura Ferré, Sara Marcó, Fatima Bosch
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
gene therapy
obesity
type 2 diabetes
BMP7
insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000377

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