Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound
Abstract Purpose We report a case of intraocular invasion of ocular surface squamous neoplasia (OSSN) through a cataract surgery wound that manifested as an anterior chamber membrane, and perform a review of the literature. Methods An 87-year-old woman with history of an incompletely excised OSSN 10...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2020-08-01
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| Series: | Ophthalmology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40123-020-00294-2 |
| _version_ | 1819102163632128000 |
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| author | Diana M. Laura Anastasia Gkiala Georgios Charonis Sotiria Palioura |
| author_facet | Diana M. Laura Anastasia Gkiala Georgios Charonis Sotiria Palioura |
| author_sort | Diana M. Laura |
| collection | DOAJ |
| description | Abstract Purpose We report a case of intraocular invasion of ocular surface squamous neoplasia (OSSN) through a cataract surgery wound that manifested as an anterior chamber membrane, and perform a review of the literature. Methods An 87-year-old woman with history of an incompletely excised OSSN 10 days prior presented with decreased vision due to an anterior chamber membranous film that seemed connected to an old cataract wound. The membrane was biopsied, and histopathology revealed dysplastic squamous epithelial cells of conjunctival origin. Ten days later the tumor expanded to cover the entire iris surface, and a modified enucleation was performed. Results Histopathology revealed invasive OSSN extending deep to the ciliary body and laterally into the anterior chamber. The patient developed a submandibular node metastasis 7 months later. Literature review revealed six cases of invasive OSSN resulting from extension through a corneal wound, with varied presentations and outcomes. Conclusion Our case is the first to report invasive OSSN presenting as an anterior chamber membrane as a result of incomplete excision of an ocular surface malignancy adjacent to a corneal wound poses a risk for intraocular tumor extension and distant metastasis. |
| first_indexed | 2024-12-22T01:30:12Z |
| format | Article |
| id | doaj.art-42449d15021047c78cc8e991b2ed8dc2 |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-12-22T01:30:12Z |
| publishDate | 2020-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-42449d15021047c78cc8e991b2ed8dc22022-12-21T18:43:31ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282020-08-01941083108810.1007/s40123-020-00294-2Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal WoundDiana M. Laura0Anastasia Gkiala1Georgios Charonis2Sotiria Palioura3Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of MedicineNational and Kapodistrian University of Athens School of MedicineAthens Vision Eye InstituteDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of MedicineAbstract Purpose We report a case of intraocular invasion of ocular surface squamous neoplasia (OSSN) through a cataract surgery wound that manifested as an anterior chamber membrane, and perform a review of the literature. Methods An 87-year-old woman with history of an incompletely excised OSSN 10 days prior presented with decreased vision due to an anterior chamber membranous film that seemed connected to an old cataract wound. The membrane was biopsied, and histopathology revealed dysplastic squamous epithelial cells of conjunctival origin. Ten days later the tumor expanded to cover the entire iris surface, and a modified enucleation was performed. Results Histopathology revealed invasive OSSN extending deep to the ciliary body and laterally into the anterior chamber. The patient developed a submandibular node metastasis 7 months later. Literature review revealed six cases of invasive OSSN resulting from extension through a corneal wound, with varied presentations and outcomes. Conclusion Our case is the first to report invasive OSSN presenting as an anterior chamber membrane as a result of incomplete excision of an ocular surface malignancy adjacent to a corneal wound poses a risk for intraocular tumor extension and distant metastasis.https://doi.org/10.1007/s40123-020-00294-2Anterior chamber membraneCataract woundConjunctival squamous cell carcinomaIntraocular extensionOSSN |
| spellingShingle | Diana M. Laura Anastasia Gkiala Georgios Charonis Sotiria Palioura Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound Ophthalmology and Therapy Anterior chamber membrane Cataract wound Conjunctival squamous cell carcinoma Intraocular extension OSSN |
| title | Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound |
| title_full | Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound |
| title_fullStr | Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound |
| title_full_unstemmed | Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound |
| title_short | Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound |
| title_sort | intraocular invasion of ocular surface squamous neoplasia through a corneal wound |
| topic | Anterior chamber membrane Cataract wound Conjunctival squamous cell carcinoma Intraocular extension OSSN |
| url | https://doi.org/10.1007/s40123-020-00294-2 |
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